Actively Recruiting
Evaluation of Fentanyl Transdermal Patch Absorption in Hemodynamically Unstable ICU Patients.
Led by Tel-Aviv Sourasky Medical Center · Updated on 2025-05-13
40
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study investigates how well fentanyl is absorbed through the skin when delivered via a transdermal patch in critically ill surgical ICU patients. It compares hemodynamically stable patients with unstable patients who require vasopressors to maintain adequate blood pressure. Fentanyl blood levels will be measured over time to assess whether absorption is impaired in unstable patients. The goal is to determine whether transdermal fentanyl is a viable option for pain management in resource-limited ICUs or in situations where intravenous fentanyl is unavailable.
CONDITIONS
Official Title
Evaluation of Fentanyl Transdermal Patch Absorption in Hemodynamically Unstable ICU Patients.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18-70 years
- Male or female patients
- Admitted to the surgical intensive care unit (ICU)
- Indications for pain management using fentanyl
You will not qualify if you...
- No clinical indication for fentanyl analgesia (e.g., pain well controlled with non-opioid medications)
- Known allergy or hypersensitivity to fentanyl
- Contraindications to fentanyl (e.g., severe constipation, hepatic failure)
- Patients infected with multidrug-resistant organisms requiring high-level isolation (biosafety level 2 or higher)
- Hemodynamically very unstable patients requiring >20 drops/hour of norepinephrine (4 mg/50 mL), with or without vasopressin support
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Tel Aviv Medical Center
Tel Aviv, Israel, Israel
Actively Recruiting
Research Team
A
Avner Leshem, MD-PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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