Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID05142605

Meaning-Centered Grief Therapy for Parents Bereaved by Cancer: A Multisite Randomized Controlled Trial

Led by University of Miami · Updated on 2026-03-24

415

Participants Needed

5

Research Sites

N/A

Total Duration

On this page

Sponsors

U

University of Miami

Lead Sponsor

N

National Institute of Nursing Research (NINR)

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are comparing three types of support programs for parents who have lost a child to cancer. The study aims to see how these programs affect symptoms of grief and depression. The programs being studied are Meaning-Centered Grief Therapy, Supportive Counseling, and Enhanced Usual Care, with the goal of helping bereaved parents cope and find meaning after their loss. Participants will receive one of the three support programs for about four months or longer if needed. Meaning-Centered Grief Therapy involves 16 weekly sessions lasting 60 to 90 minutes each, delivered via videoconferencing, with a focus on finding meaning after loss. Supportive Psychotherapy also includes 16 weekly videoconference sessions to help participants express feelings and receive support. Enhanced Usual Care consists of standard care plus additional resources. During the study, participants will be regularly assessed for changes in grief and depression using tools like the Prolonged Grief Disorder-13-R and the Center for Epidemiologic Studies Depression Scale-Revised. Other assessments include measures of anxiety, hopelessness, regret, growth, and global health. The study follows participants for up to 10 months, monitoring their progress and symptoms through questionnaires and interviews to evaluate the effects of the support programs.

CONDITIONS

Brief Title

Evaluation of Grief Therapy Approaches for Bereaved Parents

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Biological, adoptive, step-parent or legal guardian who lost a child diagnosed with cancer as self-reported
  • Age 18 years or older
  • Loss of a child diagnosed with cancer at least 6 months before enrollment
  • Elevated prolonged grief symptoms with PG-13-R scores of 30 or above
  • Resides in a state where telepsychology practice is permitted or compliant with telehealth regulations
  • English-speaking and willing to receive intervention in English
  • Individuals who are pregnant are eligible to participate
Not Eligible

You will not qualify if you...

  • Significant psychiatric disturbance preventing completion of assessments or consent
  • Inability to access a functional device for videoconferencing and decline to use a loaner device
  • Prisoners
  • Unable to provide informed consent

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (remote or in-person)

Treatment

Duration - Approximately 4 months or longer as needed

Participants receive 16 weekly therapy sessions lasting 60 to 90 minutes each, delivered through videoconferencing. Depending on group assignment, this includes Meaning-Centered Grief Therapy, Supportive Psychotherapy, or Enhanced Usual Care with additional resources.

16 weekly sessions (remote)

Trial Site Locations

Total: 5 locations

1

Stanford University (Data Collection Only)

Stanford, California, United States, 94305

Actively Recruiting

2

University of Miami

Miami, Florida, United States, 33136

Not Yet Recruiting

3

Memorial Sloan Kettering Cancer Center

New York, New York, United States, 10065

Actively Recruiting

4

Children's Hospital of Philadelphia (Data Collection Only)

Philadelphia, Pennsylvania, United States, 19104

Actively Recruiting

5

St Jude's Children's Hospital (Data collection only)

Memphis, Tennessee, United States, 38105

Actively Recruiting

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Research Team

W

Wendy G. Lichtenthal, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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