Comparing Dexmedetomidine and Sufentanil Effects on Blood Pressure and Heart Function During Scheduled Outpatient Surgery

What this Trial Is About

Researchers are investigating the effects of two anesthesia drugs, dexmedetomidine and sufentanil, during scheduled outpatient surgeries. The study aims to compare the impact of these drugs on hemodynamic stability, meaning how stable blood pressure and heart rate remain during the induction of general anesthesia. This study focuses on patients undergoing various types of surgeries such as oral, orthopedic, urological, digestive, and gynecological procedures, and addresses concerns related to opiates causing nausea, vomiting, and delayed awakening. Participants will be randomly assigned to receive either dexmedetomidine or sufentanil during the induction of general anesthesia. Dexmedetomidine will be given as a titrated intravenous bolus dose of 0.5 gkg up to a maximum of 50 g over 5 minutes. Sufentanil will be administered intravenously at a dose of 0.25 gkg, with a maximum of 20 g, at anesthetic induction. The study is double-blinded, meaning neither the patients nor the researchers know which treatment is given. The focus is on outpatient surgeries where managing pain and side effects efficiently is important. During the study, participants will be closely monitored for intraoperative hemodynamic stability within 60 minutes after anesthesia induction. Additional assessments include heart rate, blood pressure episodes, vasopressor and atropine use during surgery, and recovery in the intensive care unit on the day of surgery. Patient-reported pain and nausea will be tracked up to seven days after surgery. Researchers will also evaluate the overall success of ambulatory management, patient satisfaction, and any adverse events following surgery. The total duration of participation spans from the day of surgery to seven days post-operation.

Evaluation of the Hemodynamic Effect of Dexmedetomidine in Scheduled Outpatient Surgery