Actively Recruiting

Phase Not Applicable
Age: 18Years - 69Years
All Genders
ID07487623

Evaluation of the Hepatoprotective Effects of a Nutritional Supplement Containing Resveratrol, Quercetin, Taurine, Inulin, and Whey Protein on Biochemical, Molecular, and Clinical Markers in Patients With Liver Disease Secondary to Chronic Hepatitis C Virus Infection (RESQUETI Study)

Led by University of Guadalajara · Updated on 2026-03-23

26

Participants Needed

2

Research Sites

6 weeks

Total Duration

On this page

Sponsors

U

University of Guadalajara

Lead Sponsor

H

Hospital Civil de Guadalajara

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are studying whether a nutritional supplement containing resveratrol, quercetin, taurine, inulin, and whey protein can improve biochemical, molecular, and clinical markers in patients with liver disease caused by chronic hepatitis C infection. The trial compares this supplement to whey protein alone to see if the combination offers extra benefits for liver-related health and clinical outcomes. Participants will take either the investigational supplement or the active control (whey protein alone) daily for 12 weeks. They will attend clinic visits every 4 weeks during this period for laboratory tests and clinical evaluations to monitor progress and effects. During the study, participants will undergo assessments including liver function tests, quality of life questionnaires (CLDQ), and frailty evaluations using grip strength, timed chair stands, and balance tests. Researchers will also measure pro-inflammatory cytokines and antioxidant activity. The study aims to collect these data from enrollment through the 12-week treatment period to evaluate the supplement's impact.

CONDITIONS

Brief Title

Evaluation of the Hepatoprotective Effects of a Nutritional Supplement in Patients With Liver Disease Secondary to Chronic Hepatitis C Virus Infection (RESQUETI Study).

Who Can Participate

Age: 18Years - 69Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients with liver disease secondary to chronic hepatitis C virus infection attending the outpatient Hepatitis Clinic
  • Child-Pugh score less than 8 points
  • Age between 18 and 69 years
  • Both sexes eligible
  • Signed informed consent
Not Eligible

You will not qualify if you...

  • Alcohol consumption within the past 6 months
  • History of acute-on-chronic liver failure (ACLF)
  • Persistent hepatic encephalopathy
  • Unable to perform frailty assessments
  • Refractory ascites
  • History of hepatorenal syndrome
  • History of hepatopulmonary syndrome
  • Chronic kidney disease
  • Autoimmune diseases
  • Any type of cancer
  • Dementia or significant mental illnesses
  • Use of protein supplements or probiotics

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 12 weeks

Participants receive a powdered nutritional supplement containing resveratrol, quercetin, taurine, whey protein, and inulin or whey protein alone to assess hepatoprotective effects.

Visits at enrollment and periodic follow-ups during the 12-week treatment period

Trial Site Locations

Total: 2 locations

1

Hospital Civil de Guadalajara Fray Antonio Alcalde

Guadalajara, Jalisco, Mexico, 44280

Actively Recruiting

2

Hospital Civil de Guadalajara Fray Antonio Alcalde

Guadalajara, Jalisco, Mexico

Actively Recruiting

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Research Team

J

Juan Roberto Rodriguez-Echevarria, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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Published Research Related To This Trial

Quercetin intervention reduced hepatic fat deposition in patients with nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled crossover clinical trial.

NingChao Li, Chun Cui, Jing Xu...

https://pubmed.ncbi.nlm.nih.gov/39032786

A Phase I Dose Escalation Study Demonstrates Quercetin Safety and Explores Potential for Bioflavonoid Antivirals in Patients with Chronic Hepatitis C.

Nu T Lu, Catherine M Crespi, Natalie M Liu...

https://pubmed.ncbi.nlm.nih.gov/26621580

Randomised clinical trial: oral taurine supplementation versus placebo reduces muscle cramps in patients with chronic liver disease.

Helen Vidot, Erin Cvejic, Sharon Carey...

https://pubmed.ncbi.nlm.nih.gov/30136291

Open-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patients.

Taned Chitapanarux, Prasong Tienboon, Suwalee Pojchamarnwiputh...

https://pubmed.ncbi.nlm.nih.gov/19638084

Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial.

Shihui Chen, Xiaolan Zhao, Li Ran...

https://pubmed.ncbi.nlm.nih.gov/25577300

Resveratrol in Hepatitis C Patients Treated with Pegylated-Interferon-α-2b and Ribavirin Reduces Sleep Disturbance.

Manuela Pennisi, Gaetano Bertino, Caterina Gagliano...

https://pubmed.ncbi.nlm.nih.gov/28820468

Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease.

Forouzan Faghihzadeh, Peyman Adibi, Rahmatollah Rafiei...

https://pubmed.ncbi.nlm.nih.gov/25311610