Study of High Dose Prednisolone Use in Acute and Long-Term Inflammatory Conditions Measuring How Prednisolone Levels Change Over Time and With Different Treatments

What this Trial Is About

Researchers are investigating how prednisolone, a common anti-inflammatory drug used for conditions like asthma, allergy, and autoimmune diseases, is processed in the body when given at high doses. This study focuses on patients receiving high-dose prednisolone in both short-term acute and long-term chronic settings. The aim is to better understand differences in drug levels over time and metabolic changes, which may help tailor dosing to reduce side effects and improve treatment safety. The study involves three groups patients starting high-dose prednisolone acutely either in hospital or outpatient settings those on long-term high-dose prednisolone and patients receiving high doses of methylprednisolone or dexamethasone alongside oral prednisolone. Participants will continue their usual prednisolone treatment as part of routine care. Blood samples will be taken at various times to measure prednisolone levels and study metabolic effects. Participants will attend at least two visits where blood samples and other assessments will be done, with the timing depending on the duration of steroid treatment, ranging from 5 days up to 2 years. Researchers will monitor prednisolone pharmacokinetics and metabolic markers related to cardiovascular risk. The study includes detailed medical history, pregnancy testing for women of childbearing age, and regular follow-up to understand drug metabolism and effects over time.

Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic Setting