Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation.
Richard A Magill, William F Waters, George A Bray...
https://pubmed.ncbi.nlm.nih.gov/12887140/Actively Recruiting
Led by Leeds Beckett University · Updated on 2026-01-06
40
Participants Needed
1
Research Sites
4 weeks
Total Duration
Researchers are studying the effects of a nutritional drink called Think Tank on cognitive performance and well-being in middle-aged women aged 40 to 60. The study focuses on how this drink may impact brain functions like memory, attention, flexibility, and control after exposure to psychological and physical stress. The study also looks at stress markers such as heart rate, blood pressure, cortisol levels, mood, sleep quality, fatigue, effort, and productivity. This is a double-blind, placebo-controlled, randomized study using a crossover design to compare the drink with a placebo in combination with caffeine. Participants will attend three visits over up to eight weeks. The first visit involves health screening, familiarization with cognitive tests, and baseline assessments. During the second and third visits, participants will consume either the active nutritional formulation or a placebo drink with caffeine, followed by a stress challenge involving social and physical stress tests. Cognitive tests and stress-related measures will be taken before and after the stress exposure. The nutritional formulation contains a blend of ingredients including magnesium, creatine, L-tyrosine, phosphatidylserine, L-theanine, citicoline, and rhodiola. Throughout the study, participants will undergo various assessments including cognitive testing with CANTAB tasks, saliva samples for cortisol, heart rate and blood pressure monitoring, mood and fatigue questionnaires, and online surveys about sleep and productivity 24 hours after each test session. Side effects and physical experiences will also be recorded. The study aims to measure working memory, cognitive flexibility, sustained attention, and inhibitory control at baseline and after stress exposure with the drink or placebo.
CONDITIONS
Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.
Z
Zoe K Kolokotroni, PhD
L
Lauren J Owen, PhD
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Leeds Beckett University
Lead Sponsor
Sköshify™ Corporate HQ, 7045 Quiet Retreat Court, Niwot, CO 80503-7174
Collaborating Sponsor
You may qualify if you...
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Duration - Up to 8 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Same day as screening visit
Participants complete demographic information, baseline cognitive tests, and assessments of stress, anxiety, depression, caffeine consumption, sleep quality, and physical measurements.
1 visit (in-person)
Duration - Two sessions over up to 8 weeks
Participants attend two test sessions where they consume either the nutritional formulation with caffeine or placebo with caffeine, undergo stress induction, and complete cognitive and physiological assessments.
2 visits (in-person)
Duration - 24 hours after each test session
Participants complete online questionnaires 24 hours after each test session to assess sleep quality, productivity, and any side effects or physical experiences.
2 online assessments
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/9203170/Leeds Beckett University
Lead Sponsor
Sköshify™ Corporate HQ, 7045 Quiet Retreat Court, Niwot, CO 80503-7174
Collaborating Sponsor