Study Comparing Two Ways to Deliver Kidney Support Therapy During VA-ECMO Treatment Integrated vs Separate Connection

What this Trial Is About

This research focuses on patients undergoing veno-arterial extracorporeal membrane oxygenation VA-ECMO, a life-support technique used when the heart or lungs fail. These patients often develop acute kidney injury AKI and may need renal replacement therapy RRT. The study evaluates two main ways of delivering RRT during VA-ECMO using a separate vascular access parallel connection or integrating the RRT machine directly into the ECMO circuit integrated connection. The goal is to compare these methods, as current guidelines lack specific recommendations and the quality of RRT delivery is crucial for patient care. Participants will be randomly assigned to one of two groups. One group will receive RRT through a separate catheter parallel connection, while the other groups RRT machine will be connected directly to the ECMO circuit integrated connection. The study will monitor the duration and quality of RRT delivery over a period of up to 60 days during VA-ECMO treatment. The investigation includes measuring complications like infections, bleeding, and hemofilter lifespan associated with each method. During the study, participants will be closely monitored in intensive care units. Researchers will track hemofilter changes, thrombosis events, downtime of RRT, kidney function at hospital discharge, and other complications such as hemolysis and air embolism. The study will also record the number of days participants spend in intensive care and mortality at 30 days. This detailed monitoring will help assess the safety and performance of both RRT connection methods throughout the treatment period.

Evaluation of Integrated Versus Parallel Connection for Renal Replacement Therapy in ECMO Patients