Actively Recruiting
Evaluation of Integrated Versus Parallel Continuous Renal Replacement Therapy Connection in ECMO Patients A Randomized Controlled Trial
Led by Hospices Civils de Lyon · Updated on 2026-01-20
158
Participants Needed
12
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on patients undergoing veno-arterial extracorporeal membrane oxygenation (VA-ECMO), a life-support technique used when the heart or lungs fail. These patients often develop acute kidney injury (AKI) and may need renal replacement therapy (RRT). The study evaluates two main ways of delivering RRT during VA-ECMO: using a separate vascular access (parallel connection) or integrating the RRT machine directly into the ECMO circuit (integrated connection). The goal is to compare these methods, as current guidelines lack specific recommendations and the quality of RRT delivery is crucial for patient care. Participants will be randomly assigned to one of two groups. One group will receive RRT through a separate catheter (parallel connection), while the other group's RRT machine will be connected directly to the ECMO circuit (integrated connection). The study will monitor the duration and quality of RRT delivery over a period of up to 60 days during VA-ECMO treatment. The investigation includes measuring complications like infections, bleeding, and hemofilter lifespan associated with each method. During the study, participants will be closely monitored in intensive care units. Researchers will track hemofilter changes, thrombosis events, downtime of RRT, kidney function at hospital discharge, and other complications such as hemolysis and air embolism. The study will also record the number of days participants spend in intensive care and mortality at 30 days. This detailed monitoring will help assess the safety and performance of both RRT connection methods throughout the treatment period.
CONDITIONS
Brief Title
Evaluation of Integrated Versus Parallel Connection for Renal Replacement Therapy in ECMO Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged above 18 years
- Patient on VA-ECMO who requires the initiation of continuous RRT during VA-ECMO treatment
- Patient with a foreseeable length of stay in intensive care greater than 24 hours
You will not qualify if you...
- Patient who does not have a vascular capital allowing for the insertion of a new dialysis catheter to administer RRT and therefore cannot be randomized to the parallel connection group
- High pressures monitored on ECMO not allowing direct RRT catherter on ECMO
- Pregnant, parturient, or breastfeeding women
- Patient deprived of liberty by a judicial or administrative decision
- Patient under psychiatric care
- Patient subject to a legal protection measure (guardianship, curators)
- Patient not affiliated to a social security system
- Patient participating in another interventional research study in the field of extra purification renal
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
screening and enrollment visit
Duration - Up to 60 days
Participants receive continuous renal replacement therapy (RRT) connected either in parallel or integrated with the ECMO circuit during their VA-ECMO treatment.
Participants have continuous treatment during VA-ECMO stay with regular monitoring
Duration - Up to 60 days after treatment initiation
Participants are monitored for renal function, complications, and survival outcomes up to 60 days after treatment initiation and at hospital discharge.
Follow-up assessments at hospital discharge and up to 30 days post treatment
Trial Site Locations
Total: 12 locations
1
CHU de Bordeaux, GH Sud, Service d'anesthésie-réanimation cardiovasculaire, Hôpital cardiologique
Bordeaux, France
Actively Recruiting
2
CHU de Clermont Ferrand, Pôle de médecine péri-opératoire/Chirurgie cardiaque, Hôpital Gabriel Montpied
Clermont-Ferrand, France
Actively Recruiting
3
Centre Hospitalo Universitaire de Dijon, Unité Réanimation Cardio-Vasculaire,
Dijon, France, 21079
Actively Recruiting
4
CHU de Grenoble, Service de réanimation cardiovasculaire et thoracique, Pôle anesthésie réanimation, Hôpital Nord
Grenoble, France
Actively Recruiting
5
Centre Hospitalo Universitaire de Lille, Institut Coeur Poumon
Lille, France, 59037
Not Yet Recruiting
6
Hospices Civils de Lyon, Service d'Anesthésie-Réanimation cardiovasculaire, Hôpital Louis Pradel
Lyon, France
Actively Recruiting
7
CHU de Montpellier, Département d'anesthésie-réanimation, Pôle Cœur-poumons, Hôpital Arnaud de Villeneuve
Montpellier, France
Actively Recruiting
8
APHP, Institut de Cardiologie, Service d'anesthésie-réanimation cardiovasculaire, Hôpital de la Pitié-Salpêtrière
Paris, France
Actively Recruiting
9
APHP, Institut de cardiologie, Service de Médecine Intensive Réanimation, Hôpital Pitié-Salpêtrière
Paris, France
Actively Recruiting
10
CHU de Saint Etienne, Hôpital Bellevue, Service de Réanimation polyvalente et soins intensifs post-opératoires
Saint-Etienne, France
Actively Recruiting
11
Centre Hospitalo Universitaire de Toulouse, Hôpital Rangueil - Réanimation polyvalente
Toulouse, France, 31059
Not Yet Recruiting
12
Centre Hospitalo Universitaire de Toulouse, Unité de Chirurgie Cardiaque
Toulouse, France, 31059
Not Yet Recruiting
Research Team
F
Frank BIDAR, MD
T
Thomas RIMMELE, Professor MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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