Actively Recruiting
Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit: A Prospective Observational Study
Led by Kanuni Sultan Suleyman Training and Research Hospital · Updated on 2025-09-09
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether measurements of left ventricular function using transthoracic echocardiography (TTE) can predict the success of weaning adult intensive care unit (ICU) patients from mechanical ventilation. The study focuses on several heart function parameters, including Left Ventricular Outflow Tract Velocity Time Integral (LVOT VTI), Mitral Annular Plane Systolic Excursion (MAPSE), E/e' ratio, E/A ratio, Mitral Deceleration Time (MDT), and Myocardial Performance Index (Tei index). The goal is to understand how heart function affects the ability to stop ventilator support and improve ICU care decisions. Adult ICU patients who are on mechanical ventilation and meet weaning criteria will receive a standardized transthoracic echocardiographic exam within 2 hours. During this exam, the study team will measure the heart function parameters listed above. After this assessment, patients will be monitored for 24 hours following extubation to see if they remain off ventilatory support, including checking for any need for reintubation, non-invasive ventilation, or high-flow oxygen therapy. Participants will be closely observed during the 24 hours after extubation to determine if they successfully maintain spontaneous breathing without ventilator assistance. The study will collect echocardiographic data and clinical follow-up information to analyze the predictive value of heart function measures on weaning outcomes. This research may help guide more precise and physiologically based decisions about when and how to wean patients from mechanical ventilation, potentially reducing complications and optimizing ICU resource use.
CONDITIONS
Brief Title
Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Currently receiving mechanical ventilation in the ICU
- Planned extubation after meeting standard weaning criteria
- Hemodynamically stable at the time of echocardiographic evaluation
- Written informed consent obtained from the patient or legally authorized representative
You will not qualify if you...
- Surgery within the previous 24 hours
- Presence of significant valvular heart disease or known cardiomyopathy
- Inadequate acoustic window for transthoracic echocardiography
- Ongoing use of extracorporeal support (e.g., ECMO)
- Patients with Do-Not-Resuscitate (DNR) orders or expected to die within 24 hours
- Re-intubation planned prophylactically regardless of clinical status
- Pregnant patients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 2 hours after meeting weaning criteria
Participants who meet weaning criteria undergo a transthoracic echocardiographic (TTE) assessment to measure various left ventricular function parameters before extubation.
1 visit (in-person)
Duration - 24 hours
Participants are monitored for 24 hours after echocardiographic assessment to determine weaning success, defined as maintaining spontaneous breathing without reintubation or additional respiratory support.
Continuous monitoring during this period
Trial Site Locations
Total: 1 location
1
Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital
Istanbul, Istanbul, Turkey (Türkiye), 34303
Actively Recruiting
Research Team
E
Engin ihsan Turan, principal investigator
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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