Actively Recruiting
Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation
Led by University of Southern California · Updated on 2025-09-09
120
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate a long Clomid protocol as compared to a 5-day Clomid protocol for ovarian stimulation in patients with diminished ovarian reserve undergoing ovarian stimulation for in-vitro fertilization. The aim of the long Clomid protocol is to intensify stimulation of the ovaries and reduce both cost and injection burden for patients. Participants will be randomized to receive the long Clomid protocol vs. the typical protocol involving Clomid only for 5 days followed by growth hormone-releasing hormone (GnRH) antagonist. The primary outcome the investigators will evaluate will be the number of mature eggs retrieved.
CONDITIONS
Official Title
Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Undergoing IVF
- Must meet POSEIDON criteria based on clinic evaluation
- Female partner: Antral follicle count of 2 or more and age <45 at time of stimulation start
- Male partner/sperm source: Cannot be azoospermic
- Planning freeze-all cycle (regardless of blastocyst or cleavage stage culture) or fresh transfer if randomized to short Clomid group
- Planning 36-hour trigger window
You will not qualify if you...
- Normal ovarian reserve or good response
- Allergy or adverse reaction to Clomid
- Minimal stimulation protocols
- History of prior premature ovulation
AI-Screening
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Trial Site Locations
Total: 1 location
1
HRC Fertility
Pasadena, California, United States, 91101
Actively Recruiting
Research Team
R
Richard Paulson
CONTACT
R
Rachel Mandelbaum
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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