Actively Recruiting
Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches
Led by Medical University of South Carolina · Updated on 2025-12-18
50
Participants Needed
1
Research Sites
106 weeks
Total Duration
On this page
Sponsors
M
Medical University of South Carolina
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Tobacco-free oral nicotine pouches (such as Zyn brand) are a less harmful alternative to cigarette smoking. Pouches, however, contain nicotine, and addictive substance that is not risk-free. The present study is evaluating how well nicotine pouches, at different nicotine levels, help people switch away from smoking cigarettes. People who smoke cigarettes will be asked to answer questions about their tobacco product use and provide breath samples and cheek swab samples at an in-person visit to MUSC Charleston. Participants will then be provided with a 28-day supply of nicotine pouches, and will be asked to switch from smoking to pouches over the course of 4 weeks. Finally, participants will complete a final visit at MUSC, and will answer more questions about their tobacco use 1-month later.
CONDITIONS
Official Title
Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 21 or older
- Current cigarette smoking on 25 or more days in the past month
- Smoking 5 or more cigarettes per day for more than 1 year
- Smoked more than 100 cigarettes in lifetime
- Have not used tobacco-free nicotine pouches more than 5 times
- Willing and able to attend 2 in-person visits in Charleston
- Have internet access
You will not qualify if you...
- Not proficient in English
- Used other combustible tobacco products or non-combusted nicotine products in past 30 days
- Currently using smoking cessation medications
- Used marijuana in past month and unwilling to abstain during study
- Medical conditions that contraindicate nicotine replacement therapy (including pregnancy, breastfeeding, recent heart attack, untreated heart rhythm problems, severe angina, severe vascular disease)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
Research Team
T
Talia Ogretman
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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