Study of Lung Microbiome Changes in Adults with Nontuberculous Mycobacteria and Bronchiectasis Comparing Airway Samples from Sputum, Bronchoscopy, and Upper Airways

What this Trial Is About

Researchers are studying whether changes in the airway microbiome are linked to pulmonary Non-tuberculous mycobacteria NTM disease in people suspected of having this condition. This observational study includes 200 participants and compares those with active NTM infection to those without based on sputum or lung sample cultures. The goal is to better understand the airway bacteria differences in NTM bronchiectasis. Participants will provide induced sputum and upper airway samples to analyze the airway microbiome. A subgroup will also undergo bronchoscopy to collect lower airway samples for comparison. The study groups include individuals with positive NTM cultures and controls with negative cultures. Procedures like bronchoscopy will be used to assess the lung microbiome more directly. During the study, participants will be assessed through airway sample collection and clinical evaluations. Researchers will use tools such as the Eating Assessment Tool EAT-10, laryngoscopy, and the Reflux Symptom Index to evaluate symptoms related to airway reflux and swallowing difficulties. The primary outcome is to compare the airway microbiome between those with active pulmonary NTM disease and controls. The study includes safety and consent monitoring, with participation lasting according to study schedules.

Evaluation Of The Lung Microbiome In NTM Bronchiectasis