Actively Recruiting
Evaluation of the Microcirculatory Response to Fluids in Critically Ill Patients With Venous Congestion: A Prospective Observational Study
Led by Università Politecnica delle Marche · Updated on 2026-04-02
30
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
This observational study focuses on critically ill patients in intensive care who show signs of venous congestion. Researchers aim to evaluate how these patients' microcirculatory status changes after receiving fluids compared to those without venous congestion. The main question is whether fluid-responsive patients with venous congestion experience worsening microcirculation following fluid administration. Participants will undergo a fluid challenge after initial assessment of venous congestion signs and microcirculation. Microcirculatory measures, including total vessel density and perfused vessel density, will be recorded at baseline, immediately after the fluid challenge, and again 30 minutes later. The study does not involve a drug intervention but uses a fluid challenge as the key procedure. During the study, participants will have sublingual microcirculation monitored using various indices at three time points around the fluid challenge. Researchers will analyze changes in these microcirculatory parameters and their association with venous congestion. The study will continue through June 2026, with assessments focused on understanding microcirculatory responses in this critical care setting.
CONDITIONS
Brief Title
Evaluation of the Microcirculatory Response to Fluids in Critically Ill Patients With Venous Congestion: A Prospective Observational Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Critically ill patients admitted to the intensive care unit
- Invasive or minimally invasive hemodynamic monitoring
- Age 18 years or older
You will not qualify if you...
- Suspected or confirmed pregnancy
- Inability to access the oral cavity (e.g., facial trauma, oral bleeding)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single day
Participants have their microcirculatory status and signs of venous congestion assessed before, immediately after, and 30 minutes following a fluid challenge.
1 visit (in-person) with multiple assessments
Trial Site Locations
Total: 1 location
1
AOU delle Marche
Ancona, Italy, Italy, 60123
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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