Actively Recruiting
Evaluation of Mobility in Subjects With Severe Knee Osteoarthritis Who Are to Undergo Total Knee Replacement
Led by University Hospital, Montpellier · Updated on 2026-04-14
20
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Osteoarthritis (OA) is the most common joint disease. It is characterized by a progressive destruction of all the components of the joint, especially the cartilage. This leads to pain, loss of mobility and can be a major handicap for some patients. Gonarthrosis, or osteoarthritis of the knee, affects 30% of people between the ages of 65 and 75 and is one of the most disabling conditions. In the final stage, the only therapeutic option to relieve patients is to replace the joint with a total knee prosthesis. Thanks to the contribution of an evaluation technique based on inertial sensors (X-SENS device), our objective is to better evaluate and understand the movement deficit in knee OA subjects. The hypothesis is that, thanks to the contribution of a technique based on inertial sensors (X-SENS), the investigators can better evaluate the movement deficit of knee OA subjects. The goal is to propose specific, rapid telekinetic biomarkers, allowing a better evaluation of functional improvements following therapeutic interventions, such as a total knee replacement.
CONDITIONS
Official Title
Evaluation of Mobility in Subjects With Severe Knee Osteoarthritis Who Are to Undergo Total Knee Replacement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient over 60 years old
- Unilateral knee osteoarthritis with radiographic stage 3 or higher in the femorotibial compartment and/or stage 2 or higher in the femoropatellar compartment
- Average knee pain over 40/100 on the Visual Analogic Scale during the past month
- Indication for total knee replacement surgery
- Failure of prior medical treatment including at least one injection of corticosteroids, hyaluronic acid, or platelet-rich plasma
You will not qualify if you...
- Presence of inflammatory joint disease such as rheumatoid arthritis, spondyloarthritis, or microcrystalline pathology
- Post-traumatic osteoarthritis of the knee
- Frontal deformity of the lower limb greater than 15 degrees
- Preoperative knee stiffness greater than 15 degrees or knee mobility less than 90 degrees
- Neurological or painful spinal pathology causing deformity
- History of trauma or surgery on lower limbs in the past two years
- Presence of lower limb prosthesis such as total hip or ankle prosthesis
- Contraindications to MRI (e.g., pacemaker, cochlear implants, ferromagnetic foreign bodies)
- Contraindications to DXA (e.g., coronary stent, pacemaker, obesity with BMI over 35, weight over 200 kg)
- Under legal protection measures such as guardianship or curatorship
- Not affiliated with or benefiting from a social security system
- Lack of informed written consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital of Montpellier
Montpellier, France, 34295
Actively Recruiting
Research Team
Y
Yves-Marie PERS, MD-PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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