Actively Recruiting
Evaluation of Mood Disorders Under Biologics in Chronic Inflammatory Rheumatic Disease
Led by Centre Hospitalier Universitaire de Besancon · Updated on 2025-07-09
108
Participants Needed
1
Research Sites
258 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic inflammatory rheumatic diseases (CIRD) affect many organ systems. Painful sensations within the joints spine, hand and foot deformities, low quality of life and psychosocial status in patients with rheumatoid arthritis, spondyloarthritis and psoriatic arthritis can lead to the development of anxiety and depression. Prevalences of anxiety increase in patients suffering of CIRD, compared with healthy individuals. Another connection has been identified by the links between depression and systemic inflammation. It is proven that higher plasma levels of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNFa) affect neurotransmitter metabolism, with influence on patients mood. The purpose of EMOTION study is therefore to analyze thymic variation under TNFa therapy, as treatment of CIRDs.
CONDITIONS
Official Title
Evaluation of Mood Disorders Under Biologics in Chronic Inflammatory Rheumatic Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 to 80 years old
- Diagnosed with rheumatoid arthritis according to ACR 2010 criteria, axial or peripheral spondyloarthritis according to ASAS criteria, ankylosing spondylitis according to New York criteria, or psoriatic arthritis according to CASPAR criteria
- Signed informed consent
- Affiliated to French social security or receiving such coverage
You will not qualify if you...
- Previous treatment with anti-TNF alpha
- Previously diagnosed depressive or psychiatric conditions or currently receiving antidepressant treatment
- Limited legal capacity
- Investigator judges unlikely to comply with study procedures
- No social security coverage
- Pregnant women
- Currently in exclusion period of another study or registered in national clinical trial exclusion registry
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital
Besançon, France, 25000
Actively Recruiting
Research Team
C
Charline Vauchy, PhD
CONTACT
M
Magali Nicolier-Pallandre, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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