Actively Recruiting
Evaluation of muLtimodal and Non-invasive SPINa Bifida Neurovessels During Prospective Follow-up
Led by Rennes University Hospital · Updated on 2025-12-22
50
Participants Needed
1
Research Sites
234 weeks
Total Duration
On this page
Sponsors
R
Rennes University Hospital
Lead Sponsor
N
NeuroSphinx
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of the study is to investigate known urinary biomarkers in order to determine whether they can be predictive of a risk of damage to the upper urinary tract and therefore the kidneys in patients with spina bifida. The risk of damage to the upper urinary tract can be calculated using the Galloway score, based on the results of the urodynamic study and retrograde urethrocystography, which all patients with spina bifida have regularly. The urinary biomarkers studied TIMP-2 (Tissue inhibitor of metalloproteinases 2) and MMP-2 (matrix metalloproteinase-2) are potentially associated with renal degradation, but this has not yet been demonstrated. Volunteers to take part in the study will have their biomarkers measured at the time of their urodynamic assessment.
CONDITIONS
Official Title
Evaluation of muLtimodal and Non-invasive SPINa Bifida Neurovessels During Prospective Follow-up
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Spina bifida patients seen in the multidisciplinary consultation of the spina bifida rare disease reference centre
- Written consent to participate in the research
- Must have compulsory membership of a social security scheme
You will not qualify if you...
- Patients with a non-continuous trans ileal urinary diversion
- Patients with enterocystoplasty
- Untreated bacteriuria at the time of urodynamic assessment and urine sample collection
- History of urinary tract tumour
- History of histologically proven interstitial cystitis
- Persons under legal protection such as safeguard of justice, curatorship, or guardianship
- Persons deprived of their liberty
- Women who are pregnant
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Trial Site Locations
Total: 1 location
1
Rennes University Hospital
Rennes, CHU de Rennes, France, 35033
Actively Recruiting
Research Team
L
LOÏC JACOB
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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