Actively Recruiting
Evaluation of Muscle Involvement in Systemic Sclerosis
Led by Central Hospital, Nancy, France · Updated on 2024-08-27
150
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Muscle involvement is poorly described in patients with systemic sclerosis (SSc) . The prevalence of muscle damage is evaluated at 5-95 % of SSc patients, particularly due to variable definitions depending on the series in the scientific litterature. Muscle clinicobiological and histological presentation an response to immunosuppressive treatments are highly variable. Muscle involvement defined by creatinine kinase (CK) elevation, the presence of electromyography (EMG) abnormalities and/or muscle magnetic resonance imaging (MRI) hyperintensities and/or muscle biopsy inflammation appears to be associated with diffuse SSc, the presence of cardiac damage, and anti-PM-Scl antibodies. The main objective is to describe muscular manifestations associated with SSc. Secondary objectives are: * to compare characteristics between SSc patients with and without muscle involvement * to determine homogeneous groups of SSc patients with muscle involvement
CONDITIONS
Official Title
Evaluation of Muscle Involvement in Systemic Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with systemic sclerosis according to 2013 ACR/EULAR classification criteria
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 1 location
1
Paul Decker
Nancy, France
Actively Recruiting
Research Team
P
Paul Decker, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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