Activation of the VMO and VL during dynamic mini-squat exercises with and without isometric hip adduction.
J E Earl, R J Schmitz, B L Arnold
https://pubmed.ncbi.nlm.nih.gov/11738950Actively Recruiting
Age: 45Years - 65Years
All Genders
Healthy Volunteers
ID07471204
Muscle Oxygenation and Recovery Dynamics in Individuals With Knee Osteoarthritis: A Case-Control Study
Led by Bahçeşehir University · Updated on 2026-03-17
34
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
Sponsors
B
Bahçeşehir University
Lead Sponsor
I
Istanbul University - Cerrahpasa
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to compare muscle oxygenation and recovery in the vastus medialis obliquus (VMO) muscle of individuals with knee osteoarthritis (OA) to healthy people matched by age and sex. Knee OA is a joint disease causing pain, muscle weakness, and reduced function, affecting lower limb muscle performance. The study explores how oxygen levels in the VMO muscle change at rest, during exercise, and recovery in knee OA patients, and relates these changes to muscle strength, function, and pain. The study involves two groups: people with bilateral knee OA diagnosed by a physician and healthy volunteers without knee problems. Participants perform a mini-squat exercise combined with hip adduction to activate the VMO muscle while oxygenation is measured using a near-infrared device. Muscle strength is then tested using a machine measuring maximal knee extension force, and functional performance is assessed with a sit-to-stand test. All tests take place during a single session. Participants will rest before testing and have pain levels recorded. Researchers will analyze how muscle oxygenation relates to strength, function, and pain. The main outcome is muscle oxygenation during the session. Other measures include quadriceps strength, sit-to-stand performance, and pain intensity. The study lasts one visit per participant and does not involve ongoing follow-up. Data will be statistically compared between those with knee OA and healthy controls.
CONDITIONS
Brief Title
Evaluation of Muscle Oxygenation and Recovery Dynamics in Individuals With Knee Osteoarthritis
Who Can Participate
Age: 45Years - 65Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age between 45 and 65 years
- Body mass index (BMI) below 30 kg/m²
- Willingness to participate in the study
- Diagnosis of knee osteoarthritis confirmed by a physician according to American College of Rheumatology criteria
- Bilateral knee osteoarthritis classified as Kellgren-Lawrence grade 2 or 3
You will not qualify if you...
- Presence of another orthopedic or rheumatologic condition affecting the lower extremity
- Uncontrolled hypertension
- Presence of lower extremity arterial or venous disorders
- Presence of a neurological disease
- Cognitive, learning, or perception impairments
- Knee extension deficit
- Physical activity level exceeding 600 MET-min/week
- Physiotherapy or rehabilitation for knee osteoarthritis within the last 6 months
- Intra-articular knee injection within the past 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo a single evaluation session including assessments of muscle oxygenation, muscle strength, functional performance, and pain intensity.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Istanbul University-Cerrahpaşa, Faculty of Health Sciences, Physiotherapy and Rehabilitation Lab.
Istanbul, Büyükçekmece, Turkey (Türkiye), 34000
Actively Recruiting
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Research Team
A
Ayşem Ecem Özdemir, PT, Msc
Y
Yıldız Analay Akbaba, PT, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Relationships between physical performance and knee and hip osteoarthritis: findings from the European Project on Osteoarthritis (EPOSA).
Mark H Edwards, Suzan van der Pas, Michael Dieter Denkinger...
https://pubmed.ncbi.nlm.nih.gov/24918169Test-retest reliability, validity, and minimum detectable change of visual analog, numerical rating, and verbal rating scales for measurement of osteoarthritic knee pain.
Ahmad H Alghadir, Shahnawaz Anwer, Amir Iqbal...
https://pubmed.ncbi.nlm.nih.gov/29731662The reliability of isokinetic and isometric leg strength measures among individuals with symptoms of mild osteoarthritis.
M R Carpenter, R L Carpenter, J Peel...
https://pubmed.ncbi.nlm.nih.gov/17119524Near-infrared spectroscopy-derived muscle oxygen saturation on a 0% to 100% scale: reliability and validity of the Moxy Monitor.
Andri Feldmann, Roger Schmitz, Daniel Erlacher
https://pubmed.ncbi.nlm.nih.gov/31741352Validity and reliability of the Moxy oxygen monitor during incremental cycling exercise.
E M Crum, W J O'Connor, L Van Loo...
https://pubmed.ncbi.nlm.nih.gov/28557670Osteoarthritis.
David J Hunter, Sita Bierma-Zeinstra
https://pubmed.ncbi.nlm.nih.gov/31034380A higher intramuscular fat in vastus medialis is associated with functional disabilities and symptoms in early stage of knee osteoarthritis: a case-control study.
Masashi Taniguchi, Yoshihiro Fukumoto, Masahide Yagi...
https://pubmed.ncbi.nlm.nih.gov/37060080Alterations in quadriceps muscle cellular and molecular properties in adults with moderate knee osteoarthritis.
B Noehren, K Kosmac, R G Walton...
https://pubmed.ncbi.nlm.nih.gov/29800621