Study Comparing Nasal Ventilation Methods to Help Preterm Babies With Breathing Problems Using Lung Ultrasound

What this Trial Is About

Researchers are evaluating the effects of three types of non-invasive ventilation methodsnasal intermittent positive pressure ventilation NIPPV, nasal continuous positive airway pressure NCPAP, and nasal high flow cannula NHFCin preterm newborns born before 37 weeks of gestation who have moderate to severe respiratory distress. The study uses lung ultrasound LUS to assess ventilation outcomes such as the duration of non-invasive ventilation and other respiratory support needs during the first week of life. Participants receive one of the three ventilation methods NIPPV using a device that adjusts pressure according to distress severity, NCPAP with positive end expiratory pressure starting from 5 mbar up to 8 mbar, or NHFC with humidified heated high flow starting at 2 Lmin and increasing to 8 Lmin based on oxygen needs. Lung ultrasound and other monitoring devices track respiratory function throughout the non-invasive ventilation period. During the study, newborns are closely monitored using lung ultrasound, measurements of heart rate, respiratory rate, oxygen saturation, blood gases, and other vital signs. Researchers will measure primary outcomes like the total duration of non-invasive ventilation during the first two weeks of life. Secondary outcomes include oxygen saturation index, need for intubation, surfactant use, bronchopulmonary dysplasia grading, and hospital stay length. The total participation period covers the initial two weeks of life with ongoing assessments.

Evaluation of Nasal Non Invasive Ventilation in Management of Neonates With Respiratory Distress Using Lung Ultrasound