Actively Recruiting
Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation
Led by University of Southern California · Updated on 2025-06-11
40
Participants Needed
1
Research Sites
398 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to determine whether direct brain stimulation of specific regions and ranges improves cognition in people with Parkinsons Disease (PD) who already have a deep brain stimulator implanted. Research activities consist of 32 subjects undergoing stimulation changes to their device and being administered neurocognitive tests to evaluate the changes. An fMRI scan will also be done at baseline and at weeks 15 and 27. All subjects will undergo the stimulation changes in a randomized double blind crossover study. Evaluation of stimulation changes will be assessed through analysis of neurocognitive data.
CONDITIONS
Official Title
Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female patients who had previously undergone bilateral STN deep brain stimulation implantation
- Age >18 years old
- Stable medication regimen for at least 3 months
- Patient informed and able to give written consent
- Able to comply with all testing, follow-ups and study appointments and protocols
You will not qualify if you...
- History of epilepsy or seizure
- History of dementia
- History of major substance abuse
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Southern California Keck School of Medicine
Los Angeles, California, United States, 90033
Actively Recruiting
Research Team
D
Darrin Lee, MD PhD
CONTACT
W
Wooseong Choi, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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