Study of Advanced Neuroprostheses Providing Sensory Feedback to Reduce Phantom Limb Pain and Improve Quality of Life in Adults

What this Trial Is About

Researchers are evaluating advanced neuromodulation techniques to reduce phantom limb pain by enhancing sensory feedback in bionic prostheses. This trial focuses on Peripheral Nerve Stimulation and other stimulation methods to assess their effect on pain relief and sensory restoration. The goal is to develop neuroprostheses that provide sensory feedback to improve quality of life for people with limb amputations. The study involves several neuromodulation procedures including Peripheral Nerve Stimulation, Spinal Cord Stimulation, Dorsal Root Ganglion Stimulation, and Motor Cortex Stimulation. Each procedure involves implanting electrodes near targeted nerves or brain areas using imaging guidance and local anesthesia. Participants receive stimulation through these implanted devices to evaluate their impact on phantom limb pain. Participants will be monitored for up to six months with repeated assessments including pain scales VAS, DN4, quality of life questionnaires SF-36, sensory threshold measurements, and psychological evaluations Hospital Anxiety and Depression Scale. Researchers will track changes in pain, sensory perception, embodiment, and emotional state. The total participation includes preoperative evaluation, implantation, and follow-up visits to assess outcomes and safety of the neurostimulation treatments.

Evaluation of Neuroprosthesis with Sensory Feedback for Modulation of Phantom Limb Pain and Enhancing Quality of Life