Qualitative and quantitative assessment of accelerated liver diffusion-weighted imaging using deep-learning reconstruction in oncologic patients.
Mihaela Rata, Francesca Castagnoli, Joshua Shur...
https://pubmed.ncbi.nlm.nih.gov/41299300Actively Recruiting
Age: 18Years +
All Genders
Healthy Volunteers
ID05118555
Evaluation of New Magnetic Resonance Techniques
Led by Royal Marsden NHS Foundation Trust · Updated on 2021-11-29
2850
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are evaluating multiple new magnetic resonance (MR) imaging techniques in patients and healthy volunteers to determine their feasibility, image quality, and measurement consistency. This master protocol study aims to identify promising MR methods that may be adopted into clinical practice or further developed in larger research studies. The evaluation includes comparing new approaches with standard procedures, assessing software or hardware updates, and developing new sequences to improve imaging in relevant pathologies. The study includes three types of MR measurement evaluations. Type 1 adds new sequences to routine clinical MR exams in patients, with additional imaging lasting no more than 15 minutes and no extra contrast agents beyond routine care. Type 2 involves complete dedicated MR sessions lasting 30 to 90 minutes to evaluate new techniques during patient treatment, requiring written informed consent. Type 3 includes MR measurements in healthy volunteers to establish technique performance and repeatability, also lasting 30 to 90 minutes with informed consent. No intravenous contrast agents are administered specifically for the study. Participants will undergo MR imaging sessions according to their group, with data collected during routine or additional scans. Patients in Type 1 receive extra sequences during their standard clinical exams. Type 2 patients have scheduled research scans alongside clinical care. Volunteers in Type 3 undergo MR scans for research purposes. The research team will assess feasibility, image quality, and repeatability over a 10-year period, comparing new MR techniques with current methods and evaluating pre- and post-treatment imaging. Consent and safety protocols are followed throughout the study.
CONDITIONS
Brief Title
Evaluation of New Magnetic Resonance Techniques
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Patients undergoing routine clinical MRI exams who give verbal consent for additional imaging sequences for research
- Patients who voluntarily agree to participate by providing written informed consent
- Healthy volunteers who voluntarily agree to participate by providing written informed consent
You will not qualify if you...
- Standard MRI exclusion criteria as per MRI Local Rules apply to all participants
- Patients or volunteers unwilling to undergo additional MRI exams, for example due to claustrophobia
- Healthy volunteers without an NHS number or not registered with a general practitioner
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Single session lasting 30 to 90 minutes depending on the MR technique evaluation type
Participants undergo MRI examinations using new magnetic resonance techniques either added to routine clinical exams or as additional dedicated sessions to evaluate the new methods.
1 to 2 visits depending on participant group and MR technique evaluation
Long-term Monitoring
Duration - Up to 10 years
Participants may be observed over time to assess the feasibility, quality, repeatability, and comparison of the new MR techniques in clinical or volunteer settings.
Follow-up visits as applicable based on clinical or research needs
Trial Site Locations
Total: 1 location
1
The Royal Marsden NHS Foundation Trust
Sutton, Surrey, United Kingdom, SM2 5PT
Actively Recruiting
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Research Team
B
Bertha Adjei
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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