Actively Recruiting

Age: 18Years - 80Years
All Genders
Healthy Volunteers
ID02014389

Objective Perimetry in Normal Subjects, Glaucoma Patients, and Retinal Dystrophy Patients

Led by Sheba Medical Center · Updated on 2024-04-25

200

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating the use of objective perimetry with a chromatic multifocal pupillometer to monitor visual field defects in patients with retinal dystrophy and glaucoma. The study aims to assess the pupil light reflex (PLR) response to short and long wavelength light stimuli, comparing these measures between affected patients and healthy participants. This observational study focuses on improving the accuracy of detecting visual field defects using an advanced, computerized infrared video pupillometer. The pupillometer measures changes in pupil diameter in response to 76 small spot stimuli across a 30-degree visual field. The stimuli consist of short- and long-wavelength lights with peaks at 485 nm and 620 nm, respectively, presented at varying intensities and durations. The study includes three groups: healthy subjects as controls, patients with glaucoma, and patients with retinal dystrophy. The PLR responses are recorded during a single visit. Participants are involved in one visit where their pupil responses to light stimuli are measured. Assessments include recording the amplitude and latency of the PLR to evaluate differences in pupil reflex between healthy individuals and those with eye conditions. Researchers also monitor participant safety by excluding those with conditions that affect pupil measurement accuracy. Study participation ranges from 18 to 80 years of age, and participants provide informed consent before joining.

CONDITIONS

Brief Title

Evaluation of Objective Perimetry Using Chromatic Multifocal Pupillometer

Who Can Participate

Age: 18Years - 80Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18-80 years old.
  • Signed informed consent.
  • Pupillary reflex to light.
Not Eligible

You will not qualify if you...

  • Cloudy corneas.
  • Surgical intraocular ophthalmic procedure within the past 30 days.
  • No reactive pupils.
  • Synechia of the iris to the lens after surgery or inflammation.
  • Neovascularization.
  • Axenfeld-Rieger Syndrome.
  • Iris atrophy (ICE syndrome).
  • Iris coloboma.
  • Sphincter damage due to ischemia.
  • Sphincter damage due to trauma (tears of sphincter or diffuse damage to muscle).
  • Sphincter damage due to Herpes Zoster Uveitis.
  • Sphincter damage due to high intraocular pressure.
  • Iris tumor or cyst.
  • Ectropion uvae.
  • Adie's pupil.
  • Third nerve aberrant regeneration of the iris sphincter.
  • RP patients with Optic neuropathy with the potential of producing a positive RAPD (Relative Afferent Pupillary Defect).
  • Chronic use of myotics or mydriatics.
  • Systemic medication that have affect on pupillary reflex.
  • Any condition preventing accurate measurement or examination of the pupil.

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Single visit

Participants undergo pupil light reflex measurement using a chromatic multifocal pupillometer to assess responses to short and long wavelength light stimuli at multiple points in the visual field.

1 visit (in-person)

Trial Site Locations

Total: 1 location

1

Sheba Medical Center

Tel Litwinsky, Israel, 52621

Actively Recruiting

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Research Team

Y

Ygal Rotenstreich, MD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Published Research Related To This Trial