Actively Recruiting
Evaluation of Oral Collagen Peptides on Skin Barrier Function in Women
Led by Centre de Pharmacologie Clinique Applique a la Dermatologie · Updated on 2026-05-12
75
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
Sponsors
C
Centre de Pharmacologie Clinique Applique a la Dermatologie
Lead Sponsor
R
Rousselot BVBA
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical study aims to determine whether taking two different doses of collagen-derived peptides for three months improves facial skin barrier integrity in women with dry, sensitive skin, compared with a placebo.
CONDITIONS
Official Title
Evaluation of Oral Collagen Peptides on Skin Barrier Function in Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed an Informed Consent Form (ICF)
- Healthy female aged 45 to 70 years not followed for any skin disease
- Skin phototype II to IV according to Fitzpatrick classification
- Dry skin on the cheeks with Tewameter measurement above 15g/m²/h
- Female of non-childbearing potential or surgically sterile at least 6 months prior or post-menopausal for at least one year
- Female of childbearing potential using a highly effective birth control method for at least 1 month prior and agreeing to continue during the study
- Agreeing not to apply cosmetic products or drugs on the face (except usual cleansing products) within 24 hours before study visits
- Agreeing not to use cosmetic, medical, or aesthetic treatments on face and legs during the study
- Affiliated to a health social security system (per French Law)
You will not qualify if you...
- Body mass index (BMI) less than 17 or greater than 30 kg/m²
- Any uncontrolled diseases such as diabetes, hypertension, hyperthyroidism, or hypothyroidism
- History of eating disorders or gastrointestinal malabsorption like celiac disease, Crohn's disease, or lactose intolerance
- History of sleeve or bypass surgery
- Currently participating in another clinical study or within its exclusion period
- Known or suspected hypersensitivity to any study product components or excipients
- Known allergy to beef-derived products
- Use of collagen supplements, vitamin C, or skin-related nutraceuticals within the last 3 months
- Started prescription medications for skin conditions or other skin-affecting medications within 3 months prior
- Significant lifestyle changes in past 3 months such as diet, exercise, or skincare routines
- Skin abnormalities or dermatosis on face or legs that could interfere with the study
- Unable to be contacted in an emergency
- Unlikely to comply with study protocol due to conditions like alcoholism, drug dependency, or psychosis
- In exclusion period in the National Biomedical Research Register of the French Ministry of Health
- Protected participant under French Public Health Code articles
- Unable to communicate or cooperate with the investigator
- Received 6000 euros or more in clinical trial participation indemnities in past 12 months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
CPCAD - Centre Pharmacologie Clinique Appliqué à la Dermatologie, CHU Nice
Nice, France, 06200
Actively Recruiting
Research Team
A
Anne-Claire Cathelineau
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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