Actively Recruiting
Evaluation of Patients With Liver Disease
Led by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Updated on 2026-05-12
8050
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The proposed study aims to evaluate, investigate, and follow-up patients suffering from acute and chronic liver disease. The study will focus on understanding diseases affecting the liver. Patients participating in the study will first undergo a routine check-up as an outpatient. They will be asked to provide blood and urine samples for laboratory testing and will undergo an ultrasound of the liver. Ultrasound examinations use sound waves to determine the size and texture of the liver. After the initial visit subjects will be requested to follow-up once a year at the outpatient department for a similar check-up. Additional tests may be requested throughout the study to provide information for other research studies and individual consent will be requested. These tests may include liver biopsies, skin biopsies, and / or specialized blood, plasma, and lymphocyte examinations. Subjects that qualify for medications presently being studied may be offered the opportunity to benefit from experimental therapy.
CONDITIONS
Official Title
Evaluation of Patients With Liver Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants 2 years of age or older
- Suspected or evidence of acute or chronic liver disease, or at risk for liver disease, as evaluated by a licensed independent practitioner
- Healthy volunteers 18 years of age or older in good general health based on medical history
You will not qualify if you...
- Affected participants with significant medical illnesses that may interfere with long-term follow-up
- Healthy volunteers with any chronic medical condition including heart, kidney, or lung diseases
- Healthy volunteers taking regular medications or supplements except multivitamins or oral contraceptives
- Healthy volunteers consuming more than 1 alcoholic drink per day on average in the past 6 months
- Healthy volunteers with history of liver disease except neonatal jaundice
- Healthy volunteers with severe illness, infection, or major surgery in the past year
- Healthy volunteers with history of cancer except basal cell carcinoma removed over a year ago
- Healthy volunteers with BMI less than 18 or greater than 25
- Healthy volunteers with low hemoglobin (less than 11 for women or less than 12 for men)
- Healthy volunteers with elevated ALT levels (greater than 35 for men or 25 for women)
- Healthy volunteers with Alkaline Phosphatase 150 or higher
- Healthy volunteers with Bilirubin over 2 g/dL
- Healthy volunteers who are HIV positive, or positive for Anti-HCV, HBsAg, or Anti-HBc
- Healthy volunteers who are pregnant
- Healthy volunteers unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
P
Patricia E Alcivar
CONTACT
T
T. Jake Liang, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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