Actively Recruiting

Age: 18Years +
All Genders
ID00823563

Evaluation of Patients With Angina in the Absence of Obstructive Coronary Artery Disease

Led by Stanford University · Updated on 2025-06-05

2000

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying patients who experience chest pain or discomfort and breathlessness but do not have blockages in their heart arteries, a condition called angina or ischemia with non-obstructive coronary arteries (ANOCA/INOCA). This registry aims to understand how common these conditions are, their causes, and the best ways to diagnose them, as well as to track long-term health outcomes in this group. Participants will undergo detailed heart evaluations as part of their standard care, including coronary angiography, intravascular ultrasound, and various tests of coronary artery function such as endothelial and microvascular assessments. Data from these procedures, along with tests for myocardial bridging and other coronary abnormalities, will be collected and entered into a research database. During the study, participants may be contacted periodically by phone or email for surveys and updates on their health status at 6 months, 1 year, 3 years, 5 years, 10 years, and every 5 years thereafter. Researchers will monitor outcomes including major cardiovascular events and changes in angina symptoms over up to 15 years. This long-term follow-up will help identify specific types of ANOCA and factors linked to cardiovascular risks.

CONDITIONS

Brief Title

Evaluation of Patients With Non-obstructive Coronary Arteries

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient referred for elective coronary angiography due to suspected coronary ischemia
  • Presence of angina or anginal equivalent symptoms such as chest, back, shoulder, arm, neck, jaw discomfort, or shortness of breath triggered by exertion, stress, or certain times
  • Age 18 years or older
Not Eligible

You will not qualify if you...

  • No symptoms (e.g., pre-operative catheterization)
  • History of heart transplant
  • Age under 18 years
  • Kidney problems with creatinine over 1.5
  • Acute coronary syndrome, Tako-tsubo, low ejection fraction (<55%), cardiogenic shock, or recent ventricular arrhythmias
  • Other causes of chest pain such as pulmonary hypertension or aortic stenosis
  • Adverse reaction to medications used in testing (acetylcholine, nitroglycerin, adenosine, heparin)
  • Current use of vasoactive medications like nitroglycerin
  • Unable to give informed consent or understand study languages
  • Hearing or visual impairments that prevent normal communication
  • Participation in another study except Stanford Gene-PAD study
  • Vulnerable subjects including minors, pregnant women, economically or educationally disadvantaged, decisionally impaired, or homeless individuals

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Day of procedure (study day one)

Participants undergo comprehensive invasive evaluation including coronary angiography, intravascular imaging, and physiologic testing as part of standard care. This includes coronary pressure/flow wire testing and various challenge tests.

1 visit (in-person)

Long-term Monitoring

Duration - Up to 15 years

Participants may be contacted periodically for follow-up information such as surveys, updates on medical history, and symptom checks to assess long-term outcomes.

Follow-up contacts at 6 months, 1 year, 3 years, 5 years, 10 years, and every 5 years thereafter

Trial Site Locations

Total: 1 location

1

Stanford University School of Medicine

Stanford, California, United States, 94305

Actively Recruiting

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Research Team

V

Vedant Pargaonkar, MD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial

Accuracy of non-invasive stress testing in women and men with angina in the absence of obstructive coronary artery disease.

Vedant S Pargaonkar, Yuhei Kobayashi, Takumi Kimura...

https://pubmed.ncbi.nlm.nih.gov/30527992

Asymmetric dimethylarginine predicts impaired epicardial coronary vasomotion in patients with angina in the absence of obstructive coronary artery disease.

Rushi V Parikh, Vedant Pargaonkar, Robyn L Ball...

https://pubmed.ncbi.nlm.nih.gov/31416658

Myocardial bridging is associated with exercise-induced ventricular arrhythmia and increases in QT dispersion.

Makiko Nishikii-Tachibana, Vedant S Pargaonkar, Ingela Schnittger...

https://pubmed.ncbi.nlm.nih.gov/28921787