Actively Recruiting
Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)
Led by University of Pennsylvania · Updated on 2025-08-27
50
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to evaluate peri-radicular healing after root-end surgery using Leukocyte and Platelet Rich Fibrin. The study population includes patients diagnosed with persistent periapical pathology and scheduled for Endodontic Microsurgery at the University of Pennsylvania School of Dental Medicine, Department of Endodontics. Patients undergoing routine endodontic microsurgery and who meet the inclusion criteria will be given the opportunity to opt in to receive L-PRF in the osteotomy site to promote bone formation. Healing will be assessed radiographically and clinically at six, twelve, eighteen, and twenty-four months.
CONDITIONS
Official Title
Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form provided
- Willingness to comply with study procedures and attend all follow-up visits
- Male or female aged over 18 years
- In good general health (ASA 2 or less) with no contraindications for endodontic microsurgery
- Persistent endodontic periapical pathology classified as Class A, B, or C by Kim and Kratchman
- Intact coronal restorations with no signs of leakage or decay beneath the restoration
You will not qualify if you...
- Under 18 years old (minors)
- Suspected root fractures
- ASA classification 3 or higher
- Periapical pathology classified as Class D, E, or F by Kim and Kratchman
- History of oral or intravenous bisphosphonate use
- If the treatment team believes endodontic microsurgery and L-PRF graft is not in the patient's best interest
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Penn Dental Medicine
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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