Study of Healing After Endodontic Microsurgery Using Leukocyte and Platelet Rich Fibrin L-PRF to Treat Persistent Apical Periodontitis

What this Trial Is About

Researchers are evaluating the healing of bone around the root area after root-end surgery in patients with persistent periapical pathology. The study focuses on patients scheduled for Endodontic Microsurgery at the University of Pennsylvania School of Dental Medicine. The purpose is to assess healing with the use of Leukocyte and Platelet Rich Fibrin L-PRF, a substance rich in growth factors that may promote tissue repair. Healing will be evaluated both through clinical examination and X-rays over a two-year period. During the surgery, patients may receive L-PRF applied to the bone site where the surgery is performed. This L-PRF is prepared by collecting blood from the patient, processing it in a centrifuge to separate components, and then placing the L-PRF clot into the surgical area to support bone formation. The study follows standard endodontic microsurgery procedures with the addition of this treatment. Patients who meet the study criteria and agree to participate will have the option to receive this treatment. Participants will be monitored and assessed at 6, 12, 18, and 24 months after surgery to check the progress of bone healing around the root area. Evaluations include clinical exams and radiographic imaging to measure peri-radicular healing. The primary outcome is the healing status at 12 and 24 months. Participants will need to commit to attending these follow-up visits during the study period, which may last up to two years.

Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)