Actively Recruiting
Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)
Led by University of Pennsylvania · Updated on 2025-08-27
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the healing of bone around the root area after root-end surgery in patients with persistent periapical pathology. The study focuses on patients scheduled for Endodontic Microsurgery at the University of Pennsylvania School of Dental Medicine. The purpose is to assess healing with the use of Leukocyte and Platelet Rich Fibrin (L-PRF), a substance rich in growth factors that may promote tissue repair. Healing will be evaluated both through clinical examination and X-rays over a two-year period. During the surgery, patients may receive L-PRF applied to the bone site where the surgery is performed. This L-PRF is prepared by collecting blood from the patient, processing it in a centrifuge to separate components, and then placing the L-PRF clot into the surgical area to support bone formation. The study follows standard endodontic microsurgery procedures with the addition of this treatment. Patients who meet the study criteria and agree to participate will have the option to receive this treatment. Participants will be monitored and assessed at 6, 12, 18, and 24 months after surgery to check the progress of bone healing around the root area. Evaluations include clinical exams and radiographic imaging to measure peri-radicular healing. The primary outcome is the healing status at 12 and 24 months. Participants will need to commit to attending these follow-up visits during the study period, which may last up to two years.
CONDITIONS
Brief Title
Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form.
- Willingness to comply with all study procedures and availability for follow-up visits.
- Male or female aged over 18 years.
- Good general health with ASA classification 2 or less and no contraindications for endodontic microsurgery.
- Persistent endodontic periapical pathology Class A, B, or C according to Kim and Kratchman classification.
- Intact coronal restorations with no evidence of leakage or caries under the restoration.
You will not qualify if you...
- Minors under 18 years old.
- Suspected root fractures.
- ASA classification 3 or greater.
- Periapical pathology Class D, E, or F according to Kim and Kratchman classification.
- History of oral or intravenous bisphosphonate use.
- Patients excluded if their treatment team believes endodontic microsurgery and L-PRF graft is not in their best interest.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single procedure
Participants undergo endodontic microsurgery with Leukocyte and Platelet Rich Fibrin (L-PRF) applied to promote healing of the surgical site.
1 visit (in-person)
Duration - Up to 24 months
Participants are monitored for peri-radicular healing over time following the procedure.
Follow-up visits at 12 and 24 months
Trial Site Locations
Total: 1 location
1
Penn Dental Medicine
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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