Actively Recruiting
Evaluation of Placental Transfusion Techniques in Prevention of Prematurity Related Complications and Effect on Their Hematological Profile
Led by Alexandria University · Updated on 2026-01-16
160
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating different methods of placental transfusion in premature newborns to understand their effects on early life outcomes and blood health. The study focuses on premature infants born at or before 32 weeks gestational age, assessing how various transfusion techniques may influence their first days of life and overall prognosis. The trial compares three procedures: intact umbilical cord milking, where the cord is milked toward the baby several times before clamping; cut umbilical cord milking, involving clamping and cutting a long cord segment and milking the blood into the baby; and delayed cord clamping, where the cord is clamped after a 30- to 60-second delay with the baby placed below placenta level. A control group will not receive any placental transfusion method. Participants will be admitted to the neonatal intensive care unit within their first day of life. Researchers will measure hemoglobin levels at admission and at the end of the first, second, and third weeks of life to assess blood health. The study is randomized and open-label, with no masking. The total participation period includes monitoring through the first three weeks after birth to evaluate the effects of the transfusion methods on premature infants' hematological profiles and related complications.
CONDITIONS
Brief Title
Evaluation of Placental Transfusion Techniques in Prevention of Prematurity Related Complications and Effect on Their Hematological Profile
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Premature neonates born at or before 32 weeks gestational age regardless of birth weight
- Admitted to neonatal intensive care unit within the first day of life
You will not qualify if you...
- Major congenital anomalies such as complex cyanotic heart disease or major central nervous system anomalies
- Head trauma causing major intracranial hemorrhage
- Placental abnormalities including abruptions, placenta previa, or retroplacental hematoma
- Cord accident or avulsion at delivery
- Refusal by the obstetrician to perform the intervention
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At birth
Participants receive one of the placental transfusion techniques immediately after birth: intact umbilical milking, cut umbilical milking, delayed cord clamping, or no intervention as a control.
1 procedure (in-person)
Duration - Up to 3 weeks after birth
Participants are monitored for hematological profile and prematurity related complications during their first three weeks of life.
Visits on admission and at the end of the first, second, and third weeks
Trial Site Locations
Total: 1 location
1
Marwa Mohamed Farag
Alexandria, Egypt, 0325
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
4
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here