Actively Recruiting
Evaluation of Polygenic Risk Score for Epithelial OVarian cancEr Risk Prediction: the PROVE Study
Led by Catholic University of the Sacred Heart · Updated on 2026-03-03
1300
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
Sponsors
C
Catholic University of the Sacred Heart
Lead Sponsor
F
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to evaluate whether polygenic risk score (PRS) assessment can help predict the onset of epithelial ovarian cancer in women aged over 18, comparing those with a histologically confirmed diagnosis of epithelial ovarian or fallopian tube cancer (cases) to women with no personal history of ovarian cancer (controls). The main questions it aims to answer are: * Is there an association between PRS and the presence of epithelial ovarian cancer? * Can PRS improve the prediction of ovarian cancer risk when adjusted for other clinical factors? Researchers will compare PRS values between cases and controls to see if higher PRS percentiles are associated with an increased risk of ovarian cancer. Participants will: * Complete a questionnaire on socio-economic status, lifestyle, and dietary habits. * Undergo blood sampling, for the analysis of BRCA1-2, PALB2, RAD51C, RAD51D pathogenic variants. * Undergo PRS analysis.
CONDITIONS
Official Title
Evaluation of Polygenic Risk Score for Epithelial OVarian cancEr Risk Prediction: the PROVE Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women with a first-time diagnosis of histologically confirmed epithelial ovarian or fallopian tube cancer (cases)
- Women with no past or current diagnosis of ovarian cancer (controls)
You will not qualify if you...
- Presence of other cancers besides ovarian cancer
AI-Screening
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Trial Site Locations
Total: 1 location
1
Dipartimento Universitario di Scienze della Vita e Sanità Pubblica
Roma, Italia, Italy, 00168
Actively Recruiting
Research Team
S
Stefania Boccia
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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