Comparing Propofol Dosing by Total Body Weight Versus Adjusted Body Weight Using an Automated Closed-Loop Anesthesia Delivery System in Obese Adults

What this Trial Is About

Researchers are investigating how different methods of calculating propofol dosing affect anesthesia in obese patients. Propofol is a common intravenous anesthetic used for induction and maintenance during surgery. Obesity changes how drugs are processed in the body, making dosing challenging. This study compares dosing based on total body weight TBW to adjusted body weight ABW to see which approach better controls anesthesia without overdosing or delayed recovery. The study uses a computer-controlled closed-loop anesthesia delivery system CLADS that adjusts propofol infusion based on brain electrical activity measured by bispectral index BIS. Patients are randomly assigned to receive propofol dosing calculated either by TBW or ABW during surgery lasting more than 60 minutes. A BIS target value of 50 guides anesthesia depth, with propofol delivered continuously via an automated pump during the procedure. Participants will undergo standard assessments including monitoring of anesthesia depth, heart rate, blood pressure, and recovery after surgery. The primary outcome is the maintenance dose of propofol required during anesthesia. Secondary outcomes include consistency of anesthesia depth, system performance, early recovery, sedation levels, and intraoperative awareness. The study involves adult obese patients up to age 65 undergoing laparoscopic or non-laparoscopic surgery. Safety and drug effects are closely monitored from anesthesia start until 48 hours after surgery.

Evaluation of Propofol Dosing Based on Total Body Weight Using Closes-loop Anaesthesia Delivery System