Actively Recruiting
Evaluation of PSMA in HER2- AR+ Metastatic Breast Cancer
Led by University of Wisconsin, Madison · Updated on 2026-02-05
13
Participants Needed
1
Research Sites
262 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research is to determine the expression of prostate specific membrane antigen (PSMA) in human epidermal growth factor receptor 2 (HER2)-negative, androgen receptor (AR)-positive metastatic breast cancer, and to determine its role in resistance to the anti-androgen, bicalutamide. The investigators hypothesize that PSMA expression will correlate with resistance to anti-androgen therapies, as has been documented in prostate cancer, and this can be used to select patients most likely to benefit from these therapies in future clinical trials. 15 people with HER2-negative, AR-positive metastatic breast cancer will be enrolled and be on study for about 3 days.
CONDITIONS
Official Title
Evaluation of PSMA in HER2- AR+ Metastatic Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with metastatic HER2-negative breast cancer
- Androgen receptor expression of 10% or higher
You will not qualify if you...
- Active cancer other than breast cancer (previously treated cancers in remission allowed)
- Unable to lie flat or tolerate PET/CT scan
- Any medical condition or circumstance that may compromise safety or study compliance
- Women of childbearing potential who are pregnant or breastfeeding (negative pregnancy test required within 7 days before PET/CT)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Wisconsin School of Medicine and Public Health
Madison, Wisconsin, United States, 53705
Actively Recruiting
Research Team
R
Radiology Studies
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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