Actively Recruiting
Evaluation of Regenerative Endodontic Treatment for Immature Teeth
Led by Kafrelsheikh University · Updated on 2025-10-07
36
Participants Needed
1
Research Sites
63 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate if regenerative endodontic treatment using two different forms of demineralized dentin matrix (DDM) can effectively treat immature permanent single-rooted teeth compared to treatment using RetroMTA in patients aged 9 to 15 years. The main questions it aims to answer are: Does the use of DDM improve clinical and radiographic outcomes such as root length, dentinal wall thickness, and apex closure? Is DDM a viable bioactive alternative to RetroMTA as a coronal sealing material in regenerative endodontic procedures? Researchers will compare three groups: one using RetroMTA, one using a DDM-TheraCal LC mixture, and one using TDM-Hydrogel, to see if these materials differ in their effects on regenerative outcomes. Participants will: Undergo two treatment visits including canal disinfection, induction of bleeding to form a blood clot scaffold, Receive placement of one of the study materials over the blood clot as a coronal barrier, Have clinical examinations and CBCT imaging at baseline and multiple follow-ups up to 12 months to assess treatment success through signs, symptoms, and radiographic changes.
CONDITIONS
Official Title
Evaluation of Regenerative Endodontic Treatment for Immature Teeth
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Systemically healthy patients free of any systemic diseases
- Patients with immature permanent single-rooted teeth
- Age between 9 and 15 years
- Teeth diagnosed as either vital (asymptomatic or symptomatic irreversible pulpitis with bleeding not stopping after 5 minutes of hemostatic agent) or non-vital pulp
You will not qualify if you...
- Allergic to any drugs used in this study or with systemic illness
- Teeth grossly decayed or fractured requiring post and core restoration
- Periodontal pockets greater than 4 mm
- Radiographic evidence of apical foramen less than 1 mm
- Periapical radiolucency exceeding 10 mm
- Presence of external or internal root resorption
- History of major surgeries such as cardiac, kidney transplantation, or hemodialysis
AI-Screening
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Trial Site Locations
Total: 1 location
1
KafrelsheikhU
Kafr ash Shaykh, Kafr Elsheikh, Egypt, 33511
Actively Recruiting
Research Team
D
Dina Sarhan, Masters
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
3
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