Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID06650137

Evaluation of Diaphragmatic Stroke Ultrasound for Diagnosing Acute Respiratory Distress Causes in the Emergency Department: A Prospective Multicenter Study

Led by University Hospital, Montpellier · Updated on 2024-12-06

100

Participants Needed

2

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are investigating the use of diaphragmatic ultrasound as a diagnostic tool in adult emergency departments for patients experiencing acute respiratory distress (ARD). The study aims to evaluate the usefulness of measuring the Sum of Plateau Times (SPT) with Clinical Ultrasound in Emergency Medicine to diagnose pneumopathy during ARD. Secondary goals include assessing other ultrasound parameters like inspiratory and expiratory plateau times and their role in diagnosing COPD exacerbation and acute cardiogenic pulmonary edema. Participants aged 18 and older who come to the emergency department with ARD will receive a right diaphragmatic ultrasound performed by trained doctors using a specialized cardiac probe. The examination involves the patient sitting at a 45-degree angle while spontaneous breathing occurs. The ultrasound captures six respiratory cycles to measure specific diaphragmatic movement times. Clinical and biological data will be collected later to confirm diagnoses by expert reviewers. During the study, participants will undergo the diaphragmatic ultrasound exam and have their medical records reviewed for clinical and laboratory information. Researchers will analyze ultrasound measurements like SPT to determine their accuracy in diagnosing pneumopathy and other conditions causing respiratory distress. The study will monitor specificity, sensitivity, predictive values, and likelihood ratios related to these ultrasound parameters. Participation involves one diagnostic procedure and follow-up assessments based on medical record review, with no intervention beyond standard care.

CONDITIONS

Brief Title

Evaluation of the Relevance of Diaphragmatic Stroke Ultrasound for the Etiological Diagnosis of Acute Respiratory Distress in an Emergency Department.

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients 18 years of age or older
  • Acute respiratory distress defined by respiratory rate above 25 and/or signs of breathing difficulty such as thoraco-abdominal rocking or active abdominal breathing
  • Peripheral oxygen saturation below 90% and/or hypercapnic acidosis (pH below 7.35 and pCO2 above 45mmHg) on arterial blood gases
  • Spontaneous breathing without mechanical ventilation
  • Clinical severity score Grade 1 with signs of struggle or Grades 2 and 3 severity
Not Eligible

You will not qualify if you...

  • Adults under legal protection or guardianship
  • Refusal to consent
  • Use of non-invasive or mechanical ventilation
  • Respiratory rate above 50 breaths per minute
  • Current antibiotic treatment for infectious pneumopathy
  • Pregnant or breastfeeding women
  • History of diaphragmatic diseases
  • Illiteracy or inability to understand study purpose
  • Not affiliated with a social security scheme
  • Legal or administrative deprivation of liberty
  • Participation in another study with overlapping exclusion period

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Single assessment at presentation

Participants undergo diaphragmatic ultrasound to assist in diagnosing the cause of acute respiratory distress in the emergency department.

1 visit (in-person)

Trial Site Locations

Total: 2 locations

1

University Hospital of Nîmes

Nîmes, Gard, France, 30900

Not Yet Recruiting

2

University Hospital of Montpellier

Montpellier, Hérault, France, 34295

Actively Recruiting

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Research Team

D

DINO TIKVESA, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

1

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Published Research Related To This Trial

Management of acute exacerbations of chronic obstructive pulmonary disease (COPD). Guidelines from the Société de pneumologie de langue française (summary).

S Jouneau, M Dres, A Guerder...

https://pubmed.ncbi.nlm.nih.gov/28552256

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC.

John J V McMurray, Stamatis Adamopoulos, Stefan D Anker...

https://pubmed.ncbi.nlm.nih.gov/22611136