Comparing Regenerative Treatment Using Injectable Platelet-Rich Fibrin with Conventional Non-Surgical Root Canal Retreatment for Teeth with Apical Periodontitis

What this Trial Is About

This clinical trial is investigating whether regenerative endodontic treatment can improve healing in adult patients with apical periodontitis who have had failed root canal treatment. The study aims to compare regenerative treatment using injectable platelet-rich fibrin i-PRF to conventional non-surgical root canal retreatment, focusing on outcomes such as periapical healing, long-term success, and tooth survival. Participants are adults aged between 18 and 50 years with persistent periapical lesions requiring retreatment of single-rooted maxillary anterior teeth. Participants will be randomly assigned to one of two groups conventional non-surgical root canal retreatment or regenerative endodontic treatment involving i-PRF as a biological scaffold. Both treatments are performed under local anesthesia and rubber dam isolation. Conventional retreatment includes removal of old root canal fillings, chemomechanical preparation, and obturation with resin sealer and gutta-percha, while regenerative treatment uses i-PRF followed by mineral trioxide aggregate placement and composite restoration. All procedures follow standardized clinical protocols. Throughout the study, participants will be followed for two years with clinical and radiographic evaluations to monitor healing and treatment success. Assessments include pain levels, sensitivity tests, pulp vitality, hard tissue formation, and changes in periapical index PAI scores. Radiographs will be obtained using positioning devices to ensure consistent imaging angles. The study aims to provide evidence on the potential benefits of regenerative endodontic therapy as an alternative to conventional retreatment.

Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment