Actively Recruiting
Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment: A Clinical Study
Led by Marmara University · Updated on 2026-03-04
140
Participants Needed
1
Research Sites
78 weeks
Total Duration
On this page
Sponsors
M
Marmara University
Lead Sponsor
M
Marmara University Scientific Research Projects Unit
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial is investigating whether regenerative endodontic treatment can improve healing in adult patients with apical periodontitis who have had failed root canal treatment. The study aims to compare regenerative treatment using injectable platelet-rich fibrin (i-PRF) to conventional non-surgical root canal retreatment, focusing on outcomes such as periapical healing, long-term success, and tooth survival. Participants are adults aged between 18 and 50 years with persistent periapical lesions requiring retreatment of single-rooted maxillary anterior teeth. Participants will be randomly assigned to one of two groups: conventional non-surgical root canal retreatment or regenerative endodontic treatment involving i-PRF as a biological scaffold. Both treatments are performed under local anesthesia and rubber dam isolation. Conventional retreatment includes removal of old root canal fillings, chemomechanical preparation, and obturation with resin sealer and gutta-percha, while regenerative treatment uses i-PRF followed by mineral trioxide aggregate placement and composite restoration. All procedures follow standardized clinical protocols. Throughout the study, participants will be followed for two years with clinical and radiographic evaluations to monitor healing and treatment success. Assessments include pain levels, sensitivity tests, pulp vitality, hard tissue formation, and changes in periapical index (PAI) scores. Radiographs will be obtained using positioning devices to ensure consistent imaging angles. The study aims to provide evidence on the potential benefits of regenerative endodontic therapy as an alternative to conventional retreatment.
CONDITIONS
Brief Title
Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged between 18 and 50 years.
- Single-rooted maxillary anterior teeth with closed apices.
- Presence of periapical lesion confirmed radiographically.
- Previously treated root canal tooth requiring non-surgical retreatment.
- Tooth has not previously undergone non-surgical root canal retreatment.
- Tooth is considered restorable.
- Patient is systemically healthy.
- Patient is willing to participate and provides informed consent.
You will not qualify if you...
- Teeth without radiographic evidence of periapical lesion.
- Teeth with developmental anomalies.
- Patients with systemic diseases that may affect healing.
- Pregnant patients.
- Teeth presenting with internal or external root resorption.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single treatment visit
Participants receive either conventional non-surgical root canal retreatment or regenerative endodontic treatment using injectable platelet-rich fibrin as a biological scaffold.
1 visit (in-person)
Duration - Up to 24 months
Participants are monitored periodically over a two-year period to assess healing progression and treatment outcomes.
Periodic visits up to 24 months
Trial Site Locations
Total: 1 location
1
Marmara University
Istanbul, Turkey (Türkiye)
Actively Recruiting
Research Team
M
Melike B KAPLANOGLU
I
Idil OZDEN, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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