Actively Recruiting
Evaluation of Right Ventricular Function to Predict Weaning Success in the Intensive Care Unit: A Prospective Observational Study
Led by Kanuni Sultan Suleyman Training and Research Hospital · Updated on 2025-09-09
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate whether right ventricular function measured by transthoracic echocardiography (TTE) can predict successful weaning from mechanical ventilation in adult ICU patients. The study focuses on assessing the predictive value of TAPSE (Tricuspid Annular Plane Systolic Excursion) and other right heart parameters such as tricuspid S' velocity, right ventricular fractional area change (RV-FAC), right atrial area, and pulmonary valve acceleration time for extubation outcomes. It is a prospective observational study conducted in a single center. Participants are adult ICU patients who are mechanically ventilated and planned for weaning. They will undergo a single bedside TTE within two hours after meeting clinical weaning criteria and being hemodynamically stable. Echocardiographic measurements of right heart function will be taken as part of routine care prior to extubation. No experimental treatments are administered during the study. During the study, participants will be monitored for 24 hours after extubation to assess if they successfully maintain spontaneous breathing without needing reintubation, non-invasive ventilation, or high-flow oxygen support. Data collected will include echocardiographic parameters, clinical and demographic information, blood gas analysis, and vital signs. The primary outcome is the ability of TAPSE to predict weaning success. Secondary outcomes involve other echocardiographic variables and their correlation with extubation results. The total participation involves the echocardiography assessment and the 24-hour follow-up period.
CONDITIONS
Brief Title
Evaluation of Right Ventricular Function to Predict Weaning Success in the Intensive Care Unit
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Receiving invasive mechanical ventilation in the ICU
- Planned extubation according to standard clinical criteria
- Hemodynamically stable at the time of transthoracic echocardiography
- Ability to undergo echocardiographic assessment within 2 hours prior to extubation
- Informed consent obtained from patient or legal representative
You will not qualify if you...
- Known severe tricuspid valve disease or congenital heart disease
- Moderate to severe pericardial effusion or cardiac tamponade
- Inadequate acoustic window for transthoracic echocardiography
- Patients requiring urgent or unplanned extubation
- Use of extracorporeal life support (e.g., ECMO) at the time of assessment
- Known pulmonary embolism or acute cor pulmonale
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within hours before extubation
Participants undergo transthoracic echocardiography (TTE) within 2 hours prior to extubation to assess right ventricular function as part of routine ICU care.
1 visit (bedside in ICU)
Duration - 24 hours
Participants are monitored for 24 hours after extubation to assess weaning success and related clinical parameters.
Continuous monitoring during ICU stay
Trial Site Locations
Total: 1 location
1
Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital
Istanbul, Istanbul, Turkey (Türkiye), 34303
Actively Recruiting
Research Team
E
Engin ihsan Turan, principal investigator
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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