Actively Recruiting
Evaluation of the Role of miR-1 in the Pathogenesis and as a Biomarker in Muscular Dystrophies and Congenital Myopathies
Led by University Hospital, Clermont-Ferrand · Updated on 2026-02-25
104
Participants Needed
1
Research Sites
159 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Clermont-Ferrand
Lead Sponsor
I
iGreD, Université Clermont Auvergne
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study aims to find out if a specific blood molecule called miR-1, can be used as a biomarker to track the health of patients with certain muscle diseases. MicroRNAs (miRs) are small messengers that help control how cells grow and stay healthy. Some of these, like miR-1, are specifically found in muscles and the heart. Research shows that levels of miR-1 are often abnormal in people with muscle-wasting conditions, but more information are needed to understand how this relates to the severity of the disease. The main goal is to compare the blood levels of miR-1 between four different groups at different ages and severities: 1. Patients with Duchenne or Becker muscular dystrophy (DMD/DMB). 2. Patients with Myotonic Dystrophy Type 1 (Steinert's disease). 3. Patients with congenital myopathies. 4. Healthy volunteers (control group). The main objective is to assess if miR-1 levels can accurately show how a muscular disease is progressing.
CONDITIONS
Official Title
Evaluation of the Role of miR-1 in the Pathogenesis and as a Biomarker in Muscular Dystrophies and Congenital Myopathies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be older than 2 years of age
- Participants or their legal guardians must provide free and informed consent
- For children under 6 years old, consent is oral; for those over 6, consent is written
- Participants must be affiliated with the French social security system
- Participants must have a diagnosed neuromuscular disease: Myotonic Dystrophy Type 1, Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, congenital myopathies, or be healthy volunteers
You will not qualify if you...
- Refusal to participate by the participant or their legal guardian
- Intense or unusual physical effort within 10 days before blood draw
- Current use of treatments affecting systemic, muscular, or cardiac function that might interfere with results
- Participants under legal protection such as tutelage, curatorship, deprivation of liberty, or judicial protection
- Women who are pregnant or breastfeeding
- Presence of another disease that could interfere with biological findings according to the clinician
AI-Screening
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Trial Site Locations
Total: 1 location
1
CHU de Clermont-Ferrand
Clermont-Ferrand, France
Actively Recruiting
Research Team
L
Lise Laclautre, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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