Oral bacteria and cancer.
Sarah E Whitmore, Richard J Lamont
https://pubmed.ncbi.nlm.nih.gov/24676390/Actively Recruiting
Led by Tufts University · Updated on 2026-04-08
165
Participants Needed
1
Research Sites
52 weeks
Total Duration
Researchers are evaluating the safety and effectiveness of the Bixdo A30 Pro Ultra Compact Water Flosser when used along with a manual toothbrush in people with plaque-induced gingivitis. This randomized controlled trial aims to compare inflammation and bacterial plaque removal over an 8-week period. Participants are randomly assigned to one of two groups. The interventional group will use the Bixdo Ultra Compact Water Flosser twice daily for 8 weeks in addition to toothbrushing. The control group will use only a manual toothbrush and toothpaste provided by the study twice daily for the same duration. Throughout the 8-week study, participants will be monitored for changes in gum inflammation and plaque levels. Researchers will assess clinical parameters such as bleeding on probing and gingival indices to measure outcomes. Participants must follow study procedures, attend scheduled visits, and avoid other dental treatments or devices during the trial to ensure accurate results.
CONDITIONS
Evaluation of Safety and Efficacy of Bixdo Ultra Compact Water Flosser
M
Mabi Singh
A
Ann-Marie Billig
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Tufts University
Lead Sponsor
Guang Dong Bixdo Health Technology Co.,Ltd
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Bixdo Ultra Compact Water Flosser used with a manual toothbrush | Manual toothbrush alone |
|---|---|---|
| What it is | Participants use the Bixdo Ultra Compact Water Flosser together with a manual toothbrush for daily oral hygiene over 8 weeks. | Participants use a manual toothbrush alone, performed as study-provided routine brushing twice daily for 8 weeks. No powered or additional interdental device is used. |
| Role in the trial | This is the investigational device group, assessing if daily use of a water flosser added to standard brushing improves gingival health and plaque removal. | This is the control group, representing current recommended standard brushing practices for this patient population. |
| Primary use | Aims to reduce gingival inflammation and bacterial plaque by combining water flossing with conventional toothbrushing. | Standard oral hygiene to control gingival inflammation and plaque using manual tooth brushing alone. |
| How it is given or performed | Participants are instructed to use the Bixdo Ultra Compact Water Flosser in addition to their manual tooth brushing twice each day for 8 weeks at home following the manufacturer's instructions. | Participants brush with a study-provided manual toothbrush, twice daily for 8 weeks, without any additional devices or products. |
| Evidence status | Ongoing trial—efficacy and safety data for this specific device in moderate/severe gingivitis are not yet published. Similar water flosser devices, when added to tooth brushing, have demonstrated additional reductions in gingival inflammation and plaque in randomized trials. | Manual tooth brushing is standard care for plaque-induced gingivitis. While effective in many patients, manual brushing may not fully remove interdental plaque or eliminate gingival inflammation alone, and clinical evidence suggests benefits from supplemental interdental cleaning devices. |
| Important limitations | Effectiveness and acceptability for the Bixdo Ultra Compact Water Flosser specifically among adults with moderate or severe gingivitis is not yet established and may depend on user adherence and technique. Most published evidence for water flossers to date is from short-term studies, and not all devices or patient populations may achieve the same results. | Manual brushing alone may leave residual plaque in hard-to-reach areas, and technique or consistency can affect performance. Lack of adjunctive cleaning may limit plaque removal between teeth, and sustained long-term results require regular patient adherence. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants are asked to use either the Bixdo Ultra Compact Water Flosser or a manual toothbrush twice a day for 8 weeks.
Weekly visits for 8 weeks
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/25261053/Tufts University
Lead Sponsor
Guang Dong Bixdo Health Technology Co.,Ltd
Collaborating Sponsor