Safety Evaluation of Lipiodol Arterial Embolization to Treat Painful Hand Osteoarthritis Not Responding to Standard Treatments A Pilot Study

What this Trial Is About

Researchers are evaluating the safety and effects of arterial embolization using Lipiodol4 in patients with symptomatic hand osteoarthritis who have not responded to conventional treatments. This pilot study aims to understand the side effects and complications linked to the procedure, as well as its ability to reduce pain and improve hand function over a 6-month period. The study is sponsored by University Hospital, Grenoble, and includes patients aged 40 years and older with specific hand osteoarthritis symptoms and pain levels. Participants will undergo arterial embolization of the radial artery in the most painful hand using Lipiodol mixed with iodinated contrast medium. The procedure targets blood vessels supplying the affected joints. After treatment, patients will have regular follow-ups to monitor pain relief, swelling, joint function, and any side effects. Imaging studies such as ultrasound and arteriography will be used to assess changes in joint vascularization and damage over time. During the study, participants will be assessed for adverse events related to embolization using standard criteria from the time of treatment up to six months afterward. Pain intensity, joint swelling and tenderness, hand function, grip strength, and joint vascularization will be measured at baseline and at 1, 3, and 6 months post-treatment. Researchers will also monitor changes in the use of pain medications and hand microcirculation. The total participation duration is six months, with careful safety monitoring throughout.

Evaluation of the Safety of LipiodolⓇ Embolization in Symptomatic Digital Osteoarthritis Refractory to Conventional Treatment