Actively Recruiting
EVALUATION OF SALIVA AS LIQUID BIOPSY FOR EARLY DETECTION OF ORAL CANCER IN PATIENTS WITH ORAL-SUBMUCOUS FIBROSIS (OSMF)
Led by Liaquat University of Medical & Health Sciences · Updated on 2025-08-14
1000
Participants Needed
1
Research Sites
265 weeks
Total Duration
On this page
Sponsors
L
Liaquat University of Medical & Health Sciences
Lead Sponsor
S
Sindh Higher Education Commission
Collaborating Sponsor
AI-Summary
What this Trial Is About
Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing. Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.
CONDITIONS
Official Title
EVALUATION OF SALIVA AS LIQUID BIOPSY FOR EARLY DETECTION OF ORAL CANCER IN PATIENTS WITH ORAL-SUBMUCOUS FIBROSIS (OSMF)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy volunteers
- Patients with oral submucous fibrosis
- Patients with biopsy proven oral cancer
You will not qualify if you...
- Patients with oral infection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical Research Center
Jāmshoro, Sinch, Pakistan
Actively Recruiting
Research Team
B
Binafsha Manzoor Prof, SYed, PhD
CONTACT
F
Fasiha Dr Shah, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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