Actively Recruiting
Evaluation of Salivary Gal-7, Gal-10 and MMP-9 Levels of Individuals With Different Periodontal Diseases
Led by Izmir Katip Celebi University · Updated on 2024-10-28
60
Participants Needed
1
Research Sites
46 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is; detection of Galectin-10, Galectin-7, MMP-9 levels in saliva samples of periodontally healthy, gingivitis and periodontitis patients and the possible correlation between these values and clinical parameters of periodontal diseases. Materials and methods: Samples of saliva were obtained from 60 systemically healthy non-smoker individuals with periodontitis (P, n=20), gingivitis(G, n=20) and healthy periodontium (S, n=20). Full-mouth clinical periodontal measurements including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI) and plaque index (PI) were also recorded. Enzyme-linked immunosorbent assay (ELISA) was used to determine Galectin-10, Galectin-7 and MMP-9 levels in the biological samples.
CONDITIONS
Official Title
Evaluation of Salivary Gal-7, Gal-10 and MMP-9 Levels of Individuals With Different Periodontal Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Systemically healthy based on patient history with no additional examinations
- At least twenty permanent teeth in the mouth
- Non-smoker
- No regular medication use
- No use of antibiotics, anti-inflammatory, or corticosteroid drugs in the last 6 months
- Not pregnant or breastfeeding
- For periodontitis group: no periodontal treatment in last 6 months; at least 30% bleeding on probing, 2 or more teeth with probing depth ≥5 mm and attachment loss ≥4 mm, and bone loss visible on X-ray
- For gingivitis group: at least 10% bleeding on probing, probing depth less than 4 mm, no attachment loss
- For healthy group: less than 10% bleeding on probing, probing depth less than 4 mm, no attachment loss
You will not qualify if you...
- Any oral or systemic disease
- Regular use of systemic medication
- Pregnancy or breastfeeding
- Periodontal treatment within last 6 months
- Antibiotic, anti-inflammatory, or corticosteroid use within last 6 months
- Smoking
AI-Screening
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Trial Site Locations
Total: 1 location
1
Izmir Katip Çelebi University Department of Periodontology
Izmir, Çiğli, Turkey (Türkiye), 35640
Actively Recruiting
Research Team
C
Ceren Köksal, Research assistant
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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