Actively Recruiting
Evaluation of Salivary Galectin-8, Galectin-9 and RANKL Levels of Individuals With Different Periodontal Diseases
Led by Izmir Katip Celebi University · Updated on 2024-05-08
60
Participants Needed
1
Research Sites
59 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is; detection of Galectin-8, Galectin-9 and RANKL levels in saliva samples of periodontally healthy, gingivitis and periodontitis patients and the possible correlation between these values and clinical parameters of periodontal diseases. Materials and methods: Samples of saliva were obtained from 60 systemically healthy non-smoker individuals with periodontitis (P, n=20), gingivitis(G, n=20) and healthy periodontium (S, n=20). Full-mouth clinical periodontal measurements including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI) and plaque index (PI) were also recorded. Enzyme-linked immunosorbent assay (ELISA) was used to determine Galectin-8, Galectin-9 and RANKL levels in the biological samples.
CONDITIONS
Official Title
Evaluation of Salivary Galectin-8, Galectin-9 and RANKL Levels of Individuals With Different Periodontal Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Systemically healthy based on patient statements with no additional examinations
- At least twenty permanent teeth in the mouth
- Non-smoker
- No continuous medication use
- No use of antibiotics, anti-inflammatory or systemic corticosteroid drugs in the last 6 months
- Not pregnant or breastfeeding
- For periodontitis group: no periodontal treatment in last 6 months and specific clinical criteria including 30% or more bleeding on probing, at least 2 teeth with depth of 5 mm or more, 4 mm or more attachment loss, and bone loss seen on radiography
- For gingivitis group: 10% or more bleeding on probing, probing depth less than 4 mm, and no attachment loss
- For healthy group: less than 10% bleeding on probing, probing depth less than 4 mm, and no attachment loss
You will not qualify if you...
- Any oral or systemic disease
- Regular use of systemic medication
- Pregnancy or breastfeeding
- Received periodontal treatment within the last 6 months
- Use of antibiotic, anti-inflammatory or systemic corticosteroid medication in the last 6 months
- Smokers are excluded
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Izmir Katip Çelebi University
Izmir, Çiğli, Turkey (Türkiye), 35640
Actively Recruiting
Research Team
K
Kübra Aydın
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here