Actively Recruiting
Evaluation of the Severity of Hepatic Fibrosis by Magnetic Resonance Elastography in the Diagnosis of Endogenous Hypercorticism
Led by Central Hospital, Nancy, France · Updated on 2023-10-25
21
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the possible presence and severity of liver fibrosis in adults diagnosed with endogenous Cushing's syndrome, especially in its more severe forms. This exploratory study, known as HEPACORT, uses Magnetic Resonance Elastography (MRE) to assess liver stiffness and fibrosis in patients with confirmed or suspected Cushing's syndrome, as well as those with metabolic syndrome. The goal is to better understand liver involvement in these conditions.
CONDITIONS
Brief Title
Evaluation of the Severity of Hepatic Fibrosis by Magnetic Resonance Elastography in the Diagnosis of Endogenous Hypercorticism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Affiliated to a social security scheme or beneficiary of such a scheme
- Received complete information about the research and signed informed consent
- Completed a preliminary clinical examination suited to the research
- Patients diagnosed with Cushing's syndrome (for the Cushing's Syndrome group)
- Patients suspected of having Cushing's syndrome based on recent dexamethasone suppression test results (for the suspected Cushing's Syndrome group)
- Patients with metabolic syndrome (for the metabolic syndrome group)
You will not qualify if you...
- Taken corticosteroid therapy for more than 3 months during the 2 years before inclusion
- Taken corticosteroid therapy for less than 3 months with discontinuation less than one month before inclusion
- Taken anticortisolic treatment for more than 3 months during the 2 years before inclusion
- Have chronic liver disease
- Alcohol misuse defined as more than 10 standard units per week
- Body type that prevents MRI examination
- Women of childbearing age without effective contraception
- Contraindication to MRI examination
- Persons referred to in Articles L. 1121-5, L. 1121-7 and L1121-8 of the French Public Health Code
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo Magnetic Resonance Elastography (MRE) to assess the stiffness of liver tissues for diagnosis of hepatic fibrosis.
1 visit (in-person)
Duration - 1 year
Participants are monitored for changes in liver function and fibrosis over a 1-year period following the diagnostic evaluation.
Follow-up visits as scheduled over 1 year
Trial Site Locations
Total: 1 location
1
CHRU Nancy
Nancy, France
Actively Recruiting
Research Team
N
Nicolas SCHEYER, MD
G
Guillaume DROUOT, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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