Actively Recruiting

Phase 3
Age: 18Years +
All Genders
NCT06641089

Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response

Led by MoonLake Immunotherapeutics AG · Updated on 2026-04-29

600

Participants Needed

135

Research Sites

117 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This is a study to confirm the clinical efficacy and safety of sonelokimab compared with placebo in the treatment of adults with active psoriatic arthritis who have had a previous inadequate response or intolerance to anti-tumor necrosis factor (TNF)α therapy.

CONDITIONS

Official Title

Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Participants must be 18 years of age or older
  • Confirmed diagnosis of psoriatic arthritis based on CASPAR criteria with symptoms for at least 6 months before screening
  • Active disease with at least 3 tender and 3 swollen joints
  • Current active plaque psoriasis or a dermatologist-confirmed history of plaque psoriasis
  • Negative tests for rheumatoid factor and anti-cyclic citrullinated peptide at screening
  • Previous treatment with one or more anti-TNFb1 inhibitors for psoriatic arthritis or psoriasis with inadequate response after 3 months or stopped due to safety or tolerability after at least one dose
Not Eligible

You will not qualify if you...

  • Known allergy to sonelokimab or its ingredients
  • Known allergy or contraindication to risankizumab or its ingredients
  • Diagnosis of chronic inflammatory conditions other than psoriatic arthritis or psoriasis
  • Diagnosis of inflammatory bowel disease
  • Experienced 3 or more consecutive weeks of unexplained diarrhea in the 24 weeks before baseline
  • Diagnosed with arthritis mutilans
  • Previous treatment with sonelokimab
  • Prior use of biologic immunomodulating agents for psoriatic arthritis or psoriasis other than anti-TNFb1 agents

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 135 locations

1

Clinical Site

Avondale, Arizona, United States, 85392

Actively Recruiting

2

Clinical Site

Chandler, Arizona, United States, 85225

Completed

3

Clinical Site

Flagstaff, Arizona, United States, 86001

Completed

4

Clinical Site

Mesa, Arizona, United States, 85210

Actively Recruiting

5

Clinical Site

Phoenix, Arizona, United States, 85032

Actively Recruiting

6

Clinical Site

Scottsdale, Arizona, United States, 85260

Actively Recruiting

7

Clinical Site

Tucson, Arizona, United States, 85748

Actively Recruiting

8

Clinical Site

Jonesboro, Arkansas, United States, 72401

Actively Recruiting

9

Clinical Site

La Jolla, California, United States, 92037

Actively Recruiting

10

Clinical Site

Pomona, California, United States, 91767

Actively Recruiting

11

Clinical Site

San Diego, California, United States, 92108

Actively Recruiting

12

Clinical Site

Santa Monica, California, United States, 90404

Actively Recruiting

13

Clinical Site

Thousand Oaks, California, United States, 91360

Actively Recruiting

14

Clinical Site

Upland, California, United States, 91786

Actively Recruiting

15

Clinical Site

Avon Park, Florida, United States, 33825

Actively Recruiting

16

Clinical Site

Clearwater, Florida, United States, 33765

Actively Recruiting

17

Clinical Site

Hialeah, Florida, United States, 33016

Actively Recruiting

18

Clinical Site

Miami Gardens, Florida, United States, 33014

Actively Recruiting

19

Clinical Site

Tampa, Florida, United States, 33607

Actively Recruiting

20

Clinical Site

Zephyrhills, Florida, United States, 33542

Actively Recruiting

21

Clinical Site

Gainesville, Georgia, United States, 30501

Actively Recruiting

22

Clinical Site

Springfield, Illinois, United States, 62702

Actively Recruiting

23

Clinical Site

Lake Charles, Louisiana, United States, 70605

Actively Recruiting

24

Clinical Site

Baltimore, Maryland, United States, 21224-6821

Actively Recruiting

25

Clinical Site

Grand Blanc, Michigan, United States, 48439-2451

Actively Recruiting

26

Clinical Site

Brooklyn, New York, United States, 11201

Actively Recruiting

27

Clinical Site

Rochester, New York, United States, 14642

Actively Recruiting

28

Clinical Site

Charlotte, North Carolina, United States, 28262

Actively Recruiting

29

Clinical Site

Leland, North Carolina, United States, 28451

Actively Recruiting

30

Clinical Site

Middleburg Heights, Ohio, United States, 44130

Actively Recruiting

31

Clinical Site

Portland, Oregon, United States, 97239

Actively Recruiting

32

Clinical Site

Duncansville, Pennsylvania, United States, 16635

Actively Recruiting

33

Clinical Site

Jackson, Tennessee, United States, 38305

Actively Recruiting

34

Clinical Site

Memphis, Tennessee, United States, 38119

Actively Recruiting

35

Clinical Site

Murfreesboro, Tennessee, United States, 37128

Completed

36

Clinical Site

Allen, Texas, United States, 75013

Actively Recruiting

37

Clinical Site

Austin, Texas, United States, 78745

Actively Recruiting

38

Clinical Site

Baytown, Texas, United States, 77521

Actively Recruiting

39

Clinical Site

Colleyville, Texas, United States, 76034

Actively Recruiting

40

Clinical Site

Houston, Texas, United States, 77089

Completed

41

Clinical Site

Lubbock, Texas, United States, 79424

Actively Recruiting

42

Clinical Site

Plano, Texas, United States, 75024

Actively Recruiting

43

Clinical Site

Seattle, Washington, United States, 98122

Actively Recruiting

44

Clinical Site

Beckley, West Virginia, United States, 25801

Actively Recruiting

45

Clinical Site

Pazardzhik, Bulgaria, 4400

Actively Recruiting

46

Clinical Site

Pleven, Bulgaria, 5800

Actively Recruiting

47

Clinical Site

Plovdiv, Bulgaria, 4000

Actively Recruiting

48

Clinical Site

Plovdiv, Bulgaria, 4001

Actively Recruiting

49

Clinical Site

Plovdiv, Bulgaria, 4002

Actively Recruiting

50

Clinical Site

Plovdiv, Bulgaria, 4004

Actively Recruiting

51

Clinical Site

Rousse, Bulgaria, 7000

Actively Recruiting

52

Clinical Site

Sofia, Bulgaria, 1606

Actively Recruiting

53

Clinical Site

Sofia, Bulgaria, 1784

Actively Recruiting

54

Clinical Site

Stara Zagora, Bulgaria, 6003

Actively Recruiting

55

Clinical Site

Toronto, Ontario, Canada, M5S1B2

Actively Recruiting

56

Clinical Site

Calgary, Canada, T2N 4L7

Actively Recruiting

57

Clinical Site

Trois-Rivières, Canada, G9A 3X2

Actively Recruiting

58

Clinical Site

Waterloo, Canada, N2J 1C4

Actively Recruiting

59

Clinical Site

Winnipeg, Canada, R3A IM3

Actively Recruiting

60

Clinical Site

Brno, Czechia, 63800

Actively Recruiting

61

Clinical Site

Ostrava, Czechia, 70200

Actively Recruiting

62

Clinical Site

Studénka, Czechia, 742 13

Actively Recruiting

63

Clinical Site

Zlín, Czechia, 760 01

Actively Recruiting

64

Clinical Site

Caluire-et-Cuire, France, 69300

Actively Recruiting

65

Clinical Site

Montpellier, France, 34295

Actively Recruiting

66

Clinical Site

Narbonne, France, 11100

Completed

67

Clinical Site

Nice, France, 06001

Actively Recruiting

68

Clinical Site

Rouen, France, 76031

Actively Recruiting

69

Clinical Site

Tours, France, 37170

Actively Recruiting

70

Clinical Site

Tbilisi, Georgia, 0102

Actively Recruiting

71

Clinical Site

Tbilisi, Georgia, 0112

Actively Recruiting

72

Clinical Site

Tbilisi, Georgia, 0141

Actively Recruiting

73

Clinical Site

Tbilisi, Georgia, 0159

Actively Recruiting

74

Clinical Site

Tbilisi, Georgia, 0179

Actively Recruiting

75

Clinical Site

Tbilisi, Georgia, 0180

Actively Recruiting

76

Clinical Site

Berlin, Germany, 12161

Actively Recruiting

77

Clinical Site

Berlin, Germany, 12203

Actively Recruiting

78

Clinical Site

Berlin, Germany, 13125

Actively Recruiting

79

Clinical Site

Dresden, Germany, 01067

Actively Recruiting

80

Clinical Site

Erlangen, Germany, 91054

Actively Recruiting

81

Clinical Site

Hamburg, Germany, 20095

Actively Recruiting

82

Clinical Site

Herne, Germany, 44649

Actively Recruiting

83

Clinical Site

Munich, Germany, 80639

Actively Recruiting

84

Clinical Site

Munich, Germany, 81667

Actively Recruiting

85

Clinical Site

München, Germany, 80336

Actively Recruiting

86

Clinical Site

Budapest, Hungary, 1027

Actively Recruiting

87

Clinical Site

Budapest, Hungary, 1036

Actively Recruiting

88

Clinical Site

Budapest, Hungary, 1036

Completed

89

Clinical Site

Debrecen, Hungary, H-4032

Actively Recruiting

90

Clinical SIte

Gyula, Hungary, 5700

Actively Recruiting

91

Clinical Site

Hódmezővásárhely, Hungary, 6800

Actively Recruiting

92

Clinical Site

Nyíregyháza, Hungary, 4400

Actively Recruiting

93

Clinical Site

Székesfehérvár, Hungary, 8000

Actively Recruiting

94

Clinical Site

Szolnok, Hungary, 5000

Actively Recruiting

95

Clinical Site

Veszprém, Hungary, 8200

Actively Recruiting

96

Clinical Site

Bialystok, Poland, 15707

Actively Recruiting

97

Clinical Site

Bydgoszcz, Poland, 85-065

Actively Recruiting

98

Clinical Site

Częstochowa, Poland, 42-202

Actively Recruiting

99

Clinical Site

Elblag, Poland, 82-300

Actively Recruiting

100

Clinical Site

Gdynia, Poland, 81-384

Actively Recruiting

101

Clinical Site

Krakow, Poland, 30-002

Actively Recruiting

102

Clinical Site

Krakow, Poland, 30-149

Actively Recruiting

103

Clinical Site

Krakow, Poland, 31-501

Actively Recruiting

104

Clinical Site

Lodz, Poland, 91-363

Actively Recruiting

105

Clinical Site

Nadarzyn, Poland, 05-830

Actively Recruiting

106

Clinical Site

Poznan, Poland, 60-324

Actively Recruiting

107

Clinical Site

Poznan, Poland, 60-446

Actively Recruiting

108

Clinical Site

Poznan, Poland, 60-693

Actively Recruiting

109

Clinical Site

Poznan, Poland, 61-397

Actively Recruiting

110

Clinical Site

Sochaczew, Poland, 96-500

Actively Recruiting

111

Clinical Site

Swidnica, Poland, 58100

Actively Recruiting

112

Clinical Site

Warsaw, Poland, 00-874

Actively Recruiting

113

Clinical Site

Warsaw, Poland, 02-118

Actively Recruiting

114

Clinical Site

Warsaw, Poland, 02-665

Actively Recruiting

115

Clinical Site

Warsaw, Poland, 02-677

Actively Recruiting

116

Clinical Site

Warsaw, Poland, 03-291

Actively Recruiting

117

Clinical Site

Warsaw, Poland, 04-305

Actively Recruiting

118

Clinical Site

Wołomin, Poland, 05-200

Actively Recruiting

119

Clinical Site

Wroclaw, Poland, 51-685

Actively Recruiting

120

Clinical Site

Wroclaw, Poland, 53-673

Actively Recruiting

121

Clinical Site

A Coruña, Spain, 15006

Actively Recruiting

122

Clinical Site

Bilbao, Spain, 48013

Actively Recruiting

123

Clinical Site

Castellon, Spain, 12004

Actively Recruiting

124

Clinical Site

Madrid, Spain, 28003

Actively Recruiting

125

Clinical Site

Málaga, Spain, 29009

Actively Recruiting

126

Clinical SIte

Sabadell, Spain, 08208

Actively Recruiting

127

Clinical Site

Santiago de Compostela, Spain, 15702

Actively Recruiting

128

Clinical Site

Santiago de Compostela, Spain, 15706

Actively Recruiting

129

Clinical Site

Seville, Spain, 41009

Actively Recruiting

130

Clinical Site

Seville, Spain, 41010

Actively Recruiting

131

Clinical Site

Seville, Spain, 41013

Actively Recruiting

132

Clinical Site

Valencia, Spain, 46010

Actively Recruiting

133

Clinical Site

Westcliff-on-Sea, Essex, United Kingdom, SS0

Actively Recruiting

134

Clinical Site

Barnet, United Kingdom, EN5 3DJ

Actively Recruiting

135

Clinical Site

Leeds, United Kingdom, LS7 4SA

Actively Recruiting

Loading map...

Research Team

M

Moonlake Clinical Trial Helpdesk

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

4

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response | DecenTrialz