Actively Recruiting
Evaluation of the Stress Response in Anesthesia Use Inhalation Anesthetic (Desflurane) Versus TIVA for Bariatric Surgery
Led by G.Gennimatas General Hospital · Updated on 2026-05-06
70
Participants Needed
1
Research Sites
176 weeks
Total Duration
On this page
Sponsors
G
G.Gennimatas General Hospital
Lead Sponsor
N
National and Kapodistrian University of Athens
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare the effects of Opioid Free Anesthesia (OFA) with and without volatile anesthetics (in this case desflurane) in patients undergoing bariatric surgery. The main question it aims to answer : -Will there be a difference in the perioperative stress between patients receiving OFA with and without desflurane? Participants will undergoing sleeve gastrectomy or gastric by pass, will be administered OFA with and without desflurane and blood tests (cortisole, ACTH,dopamine, PRL, adrenaline, noradrenaline, lactate) will be collected perioperatively to compare stress in the two groups.
CONDITIONS
Official Title
Evaluation of the Stress Response in Anesthesia Use Inhalation Anesthetic (Desflurane) Versus TIVA for Bariatric Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed Informed Consent
- ASA physical status II or III
- Confirmed diagnosis of morbid obesity with approval for surgical treatment
- Scheduled for laparoscopic sleeve gastrectomy or gastric bypass surgery (R-Y bypass, SASI, SADI, or one anastomosis bypass)
- Preoperative respiratory assessment completed
- Adequate organ and bone marrow function
You will not qualify if you...
- Declining or withdrawing consent
- Unsuitable for treatment compliance as assessed by the researcher
- Bradycardia, AV block, or postural hypotension
- QTcF greater than 470 msec
- Known allergy or hypersensitivity to any administered medications
- Stop-BANG score greater than 6
- Intraoperative use of more than 8 mg prednisolone or equivalent
- History of corticosteroid use for more than 3 weeks at any time
- Participation in another clinical trial involving experimental post-operative products
- Diagnosis of depression
AI-Screening
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Trial Site Locations
Total: 1 location
1
General Hospital of Athens G. Gennimatas
Athens, Greece, 11527
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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