What this Trial Is About

This research aims to build infrastructure to systematically collect clinical data, patient-reported outcomes, and imaging data from patients receiving standard radiotherapy or brachytherapy. It focuses on patients with cancer and radiotherapy side effects, using a prospective cohort design to better understand radiation effects and long-term outcomes. The study also serves as a platform for multiple randomized controlled trials (RCTs) using an innovative cohort multiple randomized controlled trial (cmRCT) design. Participants receive their usual radiotherapy care while giving informed consent for data collection and possible random selection for future experimental interventions within the cohort. Patient-reported outcomes are collected at baseline and regular intervals during follow-up. Participants selected for experimental interventions provide additional consent, while those not selected may serve as controls without further notification. After each RCT, all cohort members receive summarized trial results. Throughout the study, researchers collect and analyze imaging data, clinical outcomes, and patient reports to compare treatment effects and understand dose-response relationships. The study tracks accrual rates over two years and aims to provide a control cohort for comparative effectiveness research. Participant involvement includes ongoing data collection and follow-up assessments, supporting long-term monitoring of radiotherapy impacts and technological innovations.

Evaluation of Technological Innovation in Radiotherapy