Actively Recruiting
Evaluation of Thiosulfate Enhanced Organ Preservation Solution in Kidney Transplantation
Led by Alp Sener · Updated on 2026-04-13
120
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
End-stage renal disease (ESRD) is a serious condition requiring dialysis or kidney transplantation. Due to the shortage of living donors, kidneys from deceased donors, including neurologically deceased donors (NDD) and donation after cardiac death donors (DCD), are increasingly used. However, these kidneys face higher risks of injury and delayed function due to lack of blood supply and cold preservation effects. Researchers are studying the addition of sodium thiosulfate (STS), a hydrogen sulfide donor, to kidney preservation solutions to improve kidney viability and transplant outcomes.
CONDITIONS
Brief Title
Evaluation of Thiosulfate Enhanced Organ Preservation Solution in Kidney Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age and over
- Diagnosed with end-stage renal disease
- Receiving a kidney transplant from a deceased donor (neurologically deceased or donation after cardiac death)
You will not qualify if you...
- Under 18 years of age
- Unable to provide informed consent
- Receiving a living donor kidney transplant
- Pregnant individuals
- Known allergy to the study medication or its components
- Undergoing multiorgan transplant such as simultaneous kidney-pancreas or liver-kidney transplants
- Currently enrolled in another interventional transplant clinical trial or a clinical trial that may affect study results
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At least 2 hours (kidney preservation) plus immediate transplant procedure
Participants receive a deceased donor kidney transplant with the kidney preserved using a hypothermic mechanical perfusion device. The preservation solution is either standard or enhanced with sodium thiosulfate (STS) to improve graft function.
1 transplant procedure visit
Duration - 12 months
Participants are monitored for graft function and overall health for up to 12 months after transplant to observe the effects of the preservation solution on delayed graft function and transplant outcomes.
Regular follow-up visits during 12 months post-transplant
Trial Site Locations
Total: 1 location
1
London Health Sciences Centre
London, Ontario, Canada, N6A 5A5
Actively Recruiting
Research Team
C
Cadence Baker
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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