Actively Recruiting

Phase Not Applicable
Age: 18Years - 65Years
All Genders
NCT06801574

Evaluation Of Three Different Anagesic Techniques In Patients Undergoing Lumbar Fixation Surgery

Led by Ataturk University · Updated on 2025-10-03

84

Participants Needed

1

Research Sites

56 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Lumbar spinal stenosis is a degenerative condition characterized by the narrowing of the space surrounding the neurovascular structures of the lumbar vertebrae, resulting from age-related changes in the intervertebral discs, ligamentum flavum, and facet joints. It commonly causes unilateral pain in the lower back, hips, and legs, often described as cramping or burning. Postoperative pain management in these cases frequently involves oral opioids or intravenous administration using patient-controlled analgesia devices. However, opioids are associated with side effects such as reduced gastrointestinal motility, urinary retention, and respiratory depression. To mitigate these issues, local anesthetic wound infiltration is widely employed by surgeons to manage postoperative pain and reduce opioid consumption following lumbar spinal surgeries. The primary aim of this study is to compare the postoperative efficacy of three different analgesic methods in patients undergoing elective lumbar fixation surgery, using the percentage change in salivary opiorphin levels as a marker. Additionally, the study seeks to evaluate the correlation between these changes and postoperative pain scores, as well as the amount of opioids consumed.

CONDITIONS

Official Title

Evaluation Of Three Different Anagesic Techniques In Patients Undergoing Lumbar Fixation Surgery

Who Can Participate

Age: 18Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients scheduled to undergo lumbar fixation surgery under general anesthesia
  • Aged between 18 and 65 years
  • American Society of Anesthesiologists physical status classification of I-II
Not Eligible

You will not qualify if you...

  • Known allergy to local anesthetics
  • Use of opioid analgesics within 48 hours before sample collection
  • History of smoking or alcohol consumption
  • Conditions affecting salivary flow such as xerostomia or prior radiotherapy
  • Infectious diseases transmissible through saliva
  • American Society of Anesthesiologists physical status classification of III or higher
  • Inability to use a patient-controlled analgesia device
  • Lack of consent to study procedures

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Ataturk University

Erzurum, Turkey (Türkiye)

Actively Recruiting

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Research Team

F

Feyza Simsek

CONTACT

C

Canan Atalay

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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Evaluation Of Three Different Anagesic Techniques In Patients Undergoing Lumbar Fixation Surgery | DecenTrialz