Study of a Toothpaste With Gum Health Active Ingredients in Adults With Gum Problems Comparing Effects on Gum Health and Plaque Over 17 Weeks

What this Trial Is About

Researchers are evaluating the effects on gum health when participants switch from a toothpaste containing a gum-health active ingredient to a fluoride toothpaste without these actives. This study focuses on people with gingival problems, aiming to understand changes in gum condition, plaque levels, and bleeding over a total period of 17 weeks. The trial uses a double-blind, randomized, controlled design to compare two types of toothpaste in adults. Participants will be randomly assigned to use one of two toothpastes twice daily at home for 13 weeks one containing a gum-health active and fluoride, and the other a fluoride toothpaste without gum-health actives. After this period, all participants will switch to the fluoride toothpaste without gum-health actives for an additional 4 weeks. The study includes dental assessments and sample collections at baseline, 4, 13, and 17 weeks to evaluate gum health and oral bacteria. During the study, participants will undergo dental exams measuring gingival condition, plaque, and bleeding on probing. Samples of gingival crevicular fluid and plaque will be collected to assess biomarkers and microbial changes. They will also complete a questionnaire about oral health impact related to periodontal disease. The study monitors these outcomes to assess changes in gum health and oral condition over the 17-week period.

Evaluation of a Toothpaste Containing a Gum Health Active in Participants With Gingival Problem