Actively Recruiting
Evaluation of Topical ATR12-351 in Adults With Netherton Syndrome
Led by Azitra Inc. · Updated on 2026-02-05
12
Participants Needed
2
Research Sites
110 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objectives of this clinical trial are to evaluate the safety and tolerability of topically applied ATR12-351, to understand what the body does to ATR12-351, and to observe treatment benefits of the drug in approximately 12 adult patients with Netherton Syndrome (NS). ATR12-351 will be applied to skin lesions on one side of the body, while the vehicle control will be applied to similar lesion on the other side of the body twice daily for 2 weeks.
CONDITIONS
Official Title
Evaluation of Topical ATR12-351 in Adults With Netherton Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years of age or older
- Confirmed mutation of the SPINK5 gene
- Skin changes consistent with Netherton syndrome affecting 20% or more of body surface area
You will not qualify if you...
- Use of biologic therapies, antibiotics, antihistamines, corticosteroids, retinoids, DMARDs, immunosuppressive agents, PDE4 inhibitors, topical calcineurin inhibitors, or topical JAK inhibitors
- Presence of open wounds or extensive excoriation preventing proper ointment application
- Participation in another clinical study or expanded access program with investigational drug/device within 30 days before screening
- Living with an immunocompromised person from baseline through 2 weeks after treatment
- History of ultraviolet phototherapy in the planned treatment area within 4 weeks before baseline
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Stanford University
Palo Alto, California, United States, 94304
Actively Recruiting
2
Yale University
New Haven, Connecticut, United States, 06519
Completed
Research Team
T
Travis Whitfill
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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