Evaluation of Radiation Treatment Effects and Outcomes in Patients With Uterine Neoplasms at Sant'Orsola Polyclinic A Single-Center Observational Study

What this Trial Is About

This research aims to systematically gather and analyze data from patients with uterine neoplasms, including endometrial and cervical cancers, treated with radiotherapy at the Sant'Orsola Polyclinic. These cancers are significant health concerns, with cervical cancer being particularly common worldwide where screening is limited. The study focuses on evaluating tumor response and potential toxicities related to different radiation doses, treatment techniques, and combination therapies, considering both newly diagnosed and previously treated cases from January 1, 2000 onward. The study collects detailed information about radiation treatment settings, including dosages, fractionation schedules, and techniques. It also considers how radiotherapy is combined with surgery and systemic therapies. Data will be gathered retrospectively and prospectively over a long observation period from January 1, 2000 to December 15, 2030, covering approximately 5000 patients. This observational study does not involve administering treatments but records real-world therapeutic strategies used at the center. Participants' medical records will be reviewed to assess tumor outcomes and any radiation-induced toxicities. Researchers will monitor local disease recurrence up to 12 months after therapy and analyze correlations with treatment and patient characteristics. The study aims to use these findings to better predict and prevent toxicities in the future, ultimately improving personalized care for women with uterine neoplasms.

Evaluation of Toxicity and Outcomes of Different Therapeutic Strategies in Patients With Uterine Neoplasms