Actively Recruiting

Age: 18Years +
FEMALE
Healthy Volunteers
NCT06398938

Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy

Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2025-08-15

129

Participants Needed

1

Research Sites

138 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

To evaluate the degree of acute and long-term intestinal, urinary and vaginal toxicity, and the impact on sexual activity of an accelerated fractionation of high dose rate interventional radiotherapy (IRT-HDR) in patients with locally advanced cervical cancer (IB2 - VA, N+/-).

CONDITIONS

Official Title

Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy

Who Can Participate

Age: 18Years +
FEMALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 6518 years
  • ECOG performance status 0 to 2
  • Histological diagnosis of squamous carcinoma and/or adenocarcinoma of the uterine cervix
  • FIGO stage IB2 to IVA (staging 2018)
  • No contraindications to having a pelvic MRI
  • Signed informed consent
Not Eligible

You will not qualify if you...

  • Age less than 18 years
  • Performance status greater than 2
  • Previous cancer within the last 10 years
  • Previous radiation treatment in the pelvic region
  • Conditions that prevent radiotherapy, such as genetic hyper-radiosensitivity syndromes, active ulcerative colitis, acute diverticulitis, severe diverticulosis, or chronic pelvic inflammation
  • Serious internal diseases that prevent chemotherapy or radiochemotherapy, including severe liver disease, heart disease, or kidney failure
  • Presence of distant metastases outside pelvic lymph nodes
  • Any significant medical condition that could interfere with study participation as judged by the investigator

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Fondazione Policlinico Universitario A. Gemelli, IRCCS

Rome, Italy, 00168

Actively Recruiting

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Research Team

V

VALENTINA LANCELLOTTA

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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