Study of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy for Locally Advanced Cervical Cancer Evaluating Toxicity and Sexual Activity

What this Trial Is About

Researchers are evaluating the effects of an accelerated high dose rate interventional radiotherapy IRT-HDR on patients with locally advanced cervical cancer, specifically stages IB2 to IVA. This observational, prospective study aims to assess both the short-term and long-term intestinal, urinary, and vaginal side effects, as well as how the treatment impacts sexual activity. The study is focused on patients receiving combined radiochemotherapy followed by this accelerated brachytherapy approach. Participants will undergo four fractions of interventional radiotherapy within one week as part of their treatment after initial radiochemotherapy. This accelerated schedule is designed to deliver high doses of radiation directly to the uterus. The study is monocentric and monitors patients closely to evaluate the overall toxicity and changes in sexual activity during and after treatment. Throughout the study, participants will be regularly assessed for gastrointestinal and urinary toxicities, both acute and late, over a period of six months. Sexual activity will also be evaluated during this timeframe. These evaluations include clinical examinations and patient-reported outcomes, allowing researchers to understand the treatments impact on quality of life. The total participation duration and detailed follow-up are structured to capture both immediate and longer-term effects of the therapy.

Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy